Microarray Analysis of Ageing-related Signatures and Their Expression in Tumors Based on a Computational Biology Approach  

作　　者：Xiaosheng Wang 

机构地区：[1]Biometric Research Branch, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA

出　　处：《Genomics, Proteomics & Bioinformatics》2012年第3期136-141,共6页基因组蛋白质组与生物信息学报（英文版）

摘　　要：Ageing and cancer have been associated with genetic and genomic changes. The identification of common signatures between ageing and cancer can reveal shared molecular mechanisms underlying them. In this study, we collected ageing-related gene signatures from ten pub- lished studies involved in six different human tissues and an online resource. We found that most of these gene signatures were tissue- specific and a few were related to multiple tissues. We performed a genome-wide examination of the expression of these signatures in various human tumor types, and found that a large proportion of these signatures were universally differentially expressed among normal vs. tumor phenotypes. Functional analyses of the highly-overlapping genes between ageing and cancer using DAVID tools have iden- tified important functional categories and pathways linking ageing with cancer. The convergent and divergent mechanisms between age- ing and cancer are discussed. This study provides insights into the biology of ageing and cancer, suggesting the possibility of potential interventions aimed at postponing ageing and preventing cancer.Ageing and cancer have been associated with genetic and genomic changes. The identification of common signatures between ageing and cancer can reveal shared molecular mechanisms underlying them. In this study, we collected ageing-related gene signatures from ten pub- lished studies involved in six different human tissues and an online resource. We found that most of these gene signatures were tissue- specific and a few were related to multiple tissues. We performed a genome-wide examination of the expression of these signatures in various human tumor types, and found that a large proportion of these signatures were universally differentially expressed among normal vs. tumor phenotypes. Functional analyses of the highly-overlapping genes between ageing and cancer using DAVID tools have iden- tified important functional categories and pathways linking ageing with cancer. The convergent and divergent mechanisms between age- ing and cancer are discussed. This study provides insights into the biology of ageing and cancer, suggesting the possibility of potential interventions aimed at postponing ageing and preventing cancer.

关 键 词：MICROARRAY Gene expression profiling Ageing-related signatures Tumor BIOINFORMATICS 

分 类 号：Q78[生物学—分子生物学] TP391.4[自动化与计算机技术—计算机应用技术]