微RNA在宫颈癌发生发展中作用及其与HPV相互关系  

The Role of microRNAs in the Pathogenesis of Cervical Cancer and Its Relationship to HPV

作　　者：朱耀魁[1] 程妮[1] 胡颖[2] 岑颖洲[2] 

机构地区：[1]暨南大学附属第一医院妇产科,广州510632 [2]暨南大学生命学院化学系,广州510632

出　　处：《生理科学进展》2012年第4期251-256,共6页Progress in Physiological Sciences

基　　金：国家自然科学基金(21310104);广东省自然科学基金(32210018);广东省医学科学技术研究基金(A2011344)资助课题

摘　　要：很多miRNA参与调控了宫颈癌的增殖、凋亡及侵袭转移等多种生物学过程,并与宫颈癌预后及易感性密切相关;HPV表达的致癌蛋白E6、E7和E5直接或间接导致了多种miRNAs,如miR-34a、miR-218、miR-29a及miR-146a等表达变化,进而导致宫颈癌的发生发展,而少数miRNAs如miR-203及miR-125b等也参与了HPV病毒DNA的复制。本文还比较详细的叙述了有关miRNA基础研究的新近成果,及其在恶性肿瘤诊疗中的潜在临床意义。A lot of miRNAs have participated in the regulation of numerous biological processes such as cell proliferation,apoptosis,invasion and migration in cervical cancer,and closely associated with prognosis and susceptibility of cervical cancer.The oncogenic proteins E6,E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218,miR-29a and miR-146a,subsequently contribute to the initiation and progression of cervical cancer.In turn,some miRNAs such as miR-203 and miR-125b also play roles in the regulation of HPV DNA duplication.In addition,the latest advances on miRNA basic research and its potential significance in the diagnosis and treatment of malignant tumors are also reviewed in this paper.

关 键 词：微RNA 宫颈癌 人乳头状瘤病毒(HPV) 

分 类 号：R363[医药卫生—病理学]