桂中地区先天性唇腭裂1021例发病因素分析  

Analysis of Risk Factors of 1 021 Patients with Congenital Cleft Lip and Palate in Central Region of Guangxi

作　　者：王伯钧[1] 韦元强[1] 玉铭[1] 秦小云[2] 韦进[1] 

机构地区：[1]柳州医学高等专科学校第一附属医院口腔中心,柳州市545002 [2]柳州医学高等专科学校,柳州市545006

出　　处：《广西医学》2012年第10期1302-1304,共3页Guangxi Medical Journal

基　　金：国家"十一.五"科技支撑计划项目(2007BAI07A17-18)

摘　　要：目的分析桂中地区先天性唇腭裂的发病因素,探讨先天性唇腭裂的预防方法。方法对桂中地区先天性唇腭裂1 021例患者的临床资料进行分析。结果 1 021例患者中,男652例,女369例,男女之比为1.77∶1;唇裂609例(59.65%),腭裂299例(29.29%),唇腭裂113例(11.07%)。患者来自农村940例(92.07%),城镇81例(7.93%),农村比例明显高于城市。发病因素前3位分别是妊娠前3个月感冒(53.57%)、孕期营养缺乏(14.40%)、孕期服药(9.30%)。孕早期经历危险因素954例占93.43%,有家族遗传病史者46例占4.51%。结论病毒感染及营养因素是先天性唇腭裂发病的主要危险因素;普及孕期卫生保健知识,以降低先天性唇腭裂出生率。Objective To explore the risk factors of congenital cleft lip and palate in central region of Guangxi,and to investigate the preventive methods of congenital cleft lip and palate.Methods A clinical data of 1021 patients with congenital cleft lip and palate in central region of Guangxi were analyzed in the study.Results Of 1 021 patients,there were 652 men and 369 women,the ratio of male to female was 1.77 ∶1,609 patients（59.65%） with cleft lip,299 patients（29.29%） with cleft palate,113 patients（11.07%） with cleft lip and palate.940 patients（92.07%） came from rural areas,81 patients（7.93%） from towns;The proportion of patients from rural areas was significantly higher than that of patients from the city.The risk factors ranked in the top three as follows：flu occurred in the first 3 months of pregnancy（53.57%）,pregnancy malnutrition（14.40%）,medicine intake during pregnancy（9.40%）.954 patients（93.43%） with congenital cleft lip and palate experienced risk factors in the early stage of pregnancy,46 patients（4.50%） had familial genetic history.Conclusion Virus infection and nutritional factors are the major risk factors of incidence of congenital cleft lip and palate.It should be paid more attention to universal health care knowledge during pregnancy to reduce the incidence of congenital cleft lip and palate.

关 键 词：先天性唇腭裂 发病因素 病毒感染 营养不良 遗传 桂中地区 

分 类 号：R780.1[医药卫生—口腔医学]