优选膝关节炎贴最佳提取工艺  

The Optimization of extraction process of knee osteoarthritis paste

作　　者：苗艳平[1] 唐伯羽 闻辉[3] 王沛[1] 贾天宝[1] 洪天一[4] 

机构地区：[1]长春中医药大学药学院,吉林长春130117 [2]长春海伯尔生物股份有限公司 [3]长春中医药大学附属医院 [4]延边大学中医学院

出　　处：《中国卫生工程学》2012年第4期329-330,332,共3页Chinese Journal of Public Health Engineering

基　　金：吉林省教育厅课题[吉教科合字(2011)第53号]

摘　　要：目的优选膝关节炎贴的最佳提取工艺。方法采用出膏率及阿魏酸的含量为评价指标,以正交试验法L9(34)优选提取工艺参数。结果乙醇浓度为工艺提取主要影响因素,其余均为次要因素。确定最佳工艺为:加70%乙醇4倍量,提取2次,每次1 h。结论在所选因素水平范围内,乙醇浓度对本方法提取效果影响最大。所选条件提取工艺稳定,可行。Objective To optimize extraction process of knee osteoarthritis paste.Methods Cream ratio and ferulic acid content were regarded as evaluation indexes.Orthogonal Test L9（34） was adopted to optimize extraction technique parameters.Results Ethanol concentration was the main factors for the process extraction,the rests were secondary factors.The best technique was as follows： 70% ethanol four times the amount of extracted twice,each time one hour.Conclusion Ethanol concentration has the greatest impact on the extraction of the method at the range of the selected factors,the selected conditions are stable and feasible.

关 键 词：工艺优化 正交设计 膝关节炎贴 阿魏酸 

分 类 号：R274.3[医药卫生—中医骨伤科学]