宫颈细胞学筛查及高危型HPV检测与宫颈组织学改变的相关性研究  

Research of the relationship between cervical cytology and HPV test and lesions in the cervical tissue

作　　者：张立冬[1] 谢威[2] 裴静[1] 赵旦[2] 

机构地区：[1]广州医学院第三附属医院妇产科,510150 [2]广州医学院第三附属医院体检中心,510150

出　　处：《中华实验和临床病毒学杂志》2012年第4期276-278,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：广东省科技计划项目基金资助（2009B030801353）

摘　　要：目的探讨宫颈细胞学及高危型HPV检测结果与宫颈组织病变的相关性，提高宫颈病变早期诊断的敏感度和特异度。方法将254例不孕患者宫颈细胞学及高危型HPV检测结果分为四组，A组：宫颈细胞学阳性、高危型HPV阳性；B组：宫颈细胞学阳性、高危型HPV阴性；C组：宫颈细胞学阴性、高危型HPV阳性；D组：宫颈细胞学阴性、高危型HPV阴性，回顾分析此四组检测数据与宫颈组织病理之间的关系；并分别回顾分析宫颈细胞学阳性及高危型HPV阳性与宫颈组织病理之间的关系，比较其敏感度和特异度。结果A组宫颈CINII级及以上的发现率显著高于B组（P〈0．01），A组、B组和C组的CINI级发现率无差异（P〉0．05）；单一宫颈细胞学检测CINII级及以上阳性的敏感度100．0％、特异度46．74％，串行高危型HPV检测后其敏感度97．22％、特异度87．16％。结论不孕症患者乃至日常体检宫颈筛查仍首选宫颈细胞学检查，宫颈细胞学串行高危型HPV检查明显降低了宫颈病变的误诊率。Objective Discussion of the relationship between cervical cytology and high-risk HPV test and lesions in the cervical tissue. Method The 254 infertile patients were graded into 4 groups based on the results of cervical cytology and high-risk HPV test. The patients in group A were the cervical cytology -positive and HPV-positive. The cervical cytology -positive and HPV-negative patients were in group B. The cervical cytology -negative and HPV-positive patients were in group C and cervical cytology -negative and HPV-negative in group D. Retrospective analysis was used in the relationship between the results and lesions in the cervical tissue. Results The incidence of CIN II and higher grade than CIN II was significant higher in group A than in group B （P 〈0.01）. The incidence of CIN I was no difference among A,B and C group （P 〉 0. 05）. The sensitivity was 100.0% and the specificity was 46.74% when cervical cytology was used to test the CIN II grade. But the sensitivity changed to 97.22% and the specificity 87. 16% when both of the cervical cytology and HPV test were used. Conclusion The cervical cytology is the first choice in cervical examination. And the accuracy will significant higher when the HPV test is used simultaneously.

关 键 词：细胞学 乳头状瘤病毒 人 病理学 

分 类 号：R737.33[医药卫生—肿瘤]