Spl和Survivin在结肠癌中的表达及意义  

Expression and signifcance of Spl and Survivin in colon cancer

作　　者：梁欢[1] 崔宝红[1] 王影[1] 梁影[1] 彭士云[1] 

机构地区：[1]哈尔滨医科大学附属第三医院检验科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2012年第4期348-353,共6页Practical Oncology Journal

摘　　要：目的观察转录因子Spl和凋亡抑制因子Survivin在结肠癌组织和癌旁正常组织中的表达，探讨其与结肠癌生物学行为和预后的关系。方法应用免疫组织化学方法检测60例结肠癌组织和25例癌旁正常组织中Spl和Survivin的表达。结果在正常组织中，Spl多呈阴性或弱阳性表达，阳性率8％（2／25），Survivin无阳性表达。结肠癌组织中Spl和Survivin阳性率表达分别为45％（27／60）和53．3％（32／60）。Spl和Survivin阳性表达率呈显著相关（P〈0．01）。Spl表达与肿瘤大小、肿瘤生长方式、TNM分期及Dukes分期显著相关。Survivin与患者分化程度、淋巴结转移、TNM分期及Dukes分期显著相关，Cox多因素分析表明Spl、Survivin和Dukes分期是预后的独立影响因素。结论Spl和Survivin对于判断结肠癌生物学行为有重要价值并可以作为判断结肠癌预后的临床指标。Objective To investigate the expressions of transcription factor Spl and Survivin in colon cancer and their relationship between biological behavior and Survival rate. Methods Immunohistochemieal techniques were used to detect the gene expressions of Spl and Survivin in 60 colon cancer specimens. Results The positive expression rates of Spl and Survivin in colon carcinoma were 45% and 53.3% ,respectively. The ex- pression of Suvivin had positive relation with the expression of Spl. There was significant correlation among the expression of Spl ,tumor size, growth pattern, TNM stage and Dukes stage （ P 〈 0.05 ）. The expression levels of Survivin were correlated with cell differentiation, metastatic lymph nodes, TNM stage and Dukes stage （ P 〈 0.05 ）. With variable and multiple variable analysis, Spl and Survivin expressions and Dukes stage were inde- pendently prognostic factors of poor survival. Conclusions Spl and Survivin expressions may serve as valuable indicators of prognosis in colon carcinoma.

关 键 词：结肠癌 转录因子SP1 SURVIVIN 预后 

分 类 号：R735.35[医药卫生—肿瘤]