宁夏回族脑梗死患者三磷酸腺苷结合盒转运子基因R219K多态性与血脂的关系  

Relation between ATP ABCA1 gene R219K polymorphism and blood-lipid in cerebral infarction patients of Ningxia Hui Autonomous Region

作　　者：张丽芳[1] 杨平[1] 顾淑娥[1] 杜彦辉[1] 

机构地区：[1]宁夏医科大学总医院神经内科,银川750004

出　　处：《中华老年心脑血管病杂志》2012年第9期958-960,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：宁夏回族自治区卫生厅医疗卫生科研计划项目(2008058)

摘　　要：目的探讨宁夏回族脑梗死患者ATP结合盒转运子(ABCA1)基因R219K多态性与血脂的关系。方法连续入选住院的回族脑梗死患者105例为脑梗死组,同期入选我院门诊回族健康体验者257例为对照组。检测血脂等生化指标,用PCR-RFLP方法测基因R219K多态性,分析其与血脂的关系。结果脑梗死组和对照组RR、RK基因型及R和K等位基因频率比较,差异无统计学意义(P>0.05)。脑梗死组KK基因型较对照组明显降低,差异有统计学意义(11.4%vs 26.8%,P<0.01)。各基因型血脂水平比较,差异无统计学意义(P>0.05)。结论 KK基因型可能是回族脑梗死患者的保护因素,其保护因素可能与血脂水平无关。Objective To study the relation between ATP ABCA1 R219K gene polymorphism and blood-lipid in cerebral infarction（CI） patients of Ningxia Hui Autonomous Region. Methods One hundred and five Hui CI patients served as a CI group and 257 healthy Hui subjects served as a control group in this study. Their biochemical markers such as serum lipid were detected. ATP ABCA1 R219K gene polymorphism was assayed by PCR-RFLP and its relation with blood-lipid was analyzed. Results The proportion of KK genotype was significantly lower in CI group than in control group（11. 4% vs 26.8% ,P〈0.01）. No significant difference was observed in the serum lipid level between the two groups（P〉0.05）. Conclusion KK genotype may be a protective fac- tor for CI in Hui subjects and is related with the bolld-lipid level.

关 键 词：脑梗死 ATP结合匣式转运子 多态性 单核苷酸 血脂异常 基因型 基因频率 

分 类 号：R743.3[医药卫生—神经病学与精神病学]