降纤酶治疗急性脑梗死疗效观察  

Observation on Therapeutic Effect of Defibrase on Acute Cerebal Infarction

作　　者：杨灵山[1] 肖志恒[1] 谢荣 牛晓珊 帕丽达 吴琳 高红 龙江 帕尔哈堤 

机构地区：[1]新疆自治区人民医院神经内科,新疆830001

出　　处：《蛇志》2000年第2期28-30,共3页Journal of Snake

摘　　要：目的　观察降纤酶治疗急性脑梗死疗效。　方法　将病例随机分为 :试验组 30例 ,应用降纤酶 1 0 u、5u、 5u各加生理盐水 1 0 0 ml静脉滴注 ,隔天 1次 ,共 3次 ,治疗前后监测纤维蛋白原 (FG) ;对照组 1 5例 ,用东菱克栓酶其剂量及用法与试验组相同。同时两组应用 70 6代血浆等药物治疗。　结果　试验组基本痊愈 34 .97% ,显著进步 55.0 3% ,进步 4 % ,无变化 3% ,无恶化、死亡病例 ,总有效率达 93.97% ,无出血病例。对照组基本治愈 55.55% ,显著进步 2 5.0 % ,总有效率 80 .55%。两组比较无明显差异。试验组 FG在用药前后有明显差异。结论　降纤酶治疗急性脑梗死是安全。Objective To observe the therapeutic effect of defibrase on acute cerebral infarction Methords The test group of 30 cases were treated with defibrase in 10u,5u and 5u plus NS 100ml by intravenous drip for 3 times once every the other dayFG was observed before and after the treatment and FG variations were detected before and after the treatmentThe control group of 15 cases were treated with dongling antithrombus in the same way and dosageHowever,both broups used 706 plasma substitute and other medicine Results The recovery rate of test group was 3497%,marded improvement rate 553%,improvement rate 6%,nonimprovement 3%,without any aggravating or dead caseThe general effective rate was 937%There was no bleeding caseThe comparison of the test group and control group showed that there was no marded therapeutic difference between defibrase and donglin antithrombusBut test group showed marked difference in FG before and after the medicine was applied Conclusion Defibrase orived safe and effective for acute cerebral infarction

关 键 词：降纤酶 急性脑梗死 纤维蛋白原 疗效试验 

分 类 号：R743.305[医药卫生—神经病学与精神病学] R973.2[医药卫生—临床医学]