胃印戒细胞癌的临床病理特征及耐药基因表达特点分析  

Clinicopathological characteristics of stomach signet-cell carcinoma and analysis of the expression of multidrug resistance gene

作　　者：吕春燕[1] 张莉[1] 徐华[1] 夏仙根[1] 斯露[1] 马立[1] 陈鲜 高采平[3] 

机构地区：[1]成都市第五人民医院,成都611130 [2]成都市363医院 [3]四川省人民医院

出　　处：《山东医药》2012年第31期38-40,共3页Shandong Medical Journal

摘　　要：目的探讨胃印戒细胞癌的病理学及P-糖蛋白(P-gp)、谷胱甘肽转移酶(GST-π)、拓扑异构酶Ⅱ(TopoⅡ)的表达特点,进一步提高其诊治水平。方法分析32例胃印戒细胞癌(胃镜活检标本21例,大部切除胃标本11例)的临床病理及GST-π、P-gp、TopoⅡ的表达特点。结果胃镜下以经典型印戒细胞数量最多,弥漫性生长;相关基因检测结果显示,GST-π、P-gp、TopoⅡ阳性表达率与同期32例高—中分化腺癌比较,GST-π阳性率无显著差异,P-gp阳性率明显升高,TopoⅡ阳性率明显降低(P均<0.05)。结论胃印戒细胞癌以典型印戒细胞数量最多,且呈弥漫性生长;GST-π、P-gp、TopoⅡ的表达检测有助于胃印戒细胞癌诊断。Objective To investigate the pathology and expression of glutathione S-Transferase（GST）-π, P-glycopro- tein （ P-gp）, Topoisomerase （ Topo Ⅱ ） in signet-ring cell carcinoma of the stomach, and to further improve the level of di- agnosis and treatment. Methods The clinic and histological feature of 32 signet-ring carcinoma of stomach （21 of the 32 specimens are gained by gastroscopy, the others are obtained by partial resection of stomach）and the expression of GST-π, P-gp, Topo Ⅱ were analyzed. Results Under the microscope, the number of classic type of signet-ring cell was the most one, which grew diffusely. Compared with the 32 cases of high-medium differentiated adenoearcinoma at the same period, detection of related genes showed that there was no significant difference between positive rate of GST- π, while the positive rate of P-gp significantly increased, the positive rate of Topo Ⅱ significantly reduced （ both P 〈 0.05 ）. Conclusions The number of classic type of signet-ring cell is the most one in signet-ring carcinoma of stomach, which grow diffusely. The de- tection of GST- π, P-gp, Topo Ⅱ expression contributes to the treatment of gastric signet ring cell carcinoma.

关 键 词：胃 印戒细胞癌 病理学特征 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]