胃癌高发区胃病患者胃液内杂色曲霉提取液的遗传毒性研究  

THE GENOTOXIC EFFECTS OF EXTRACT OF ASPERGILLUS VERSICOLOR IN GASTRIC JUICE OF PATIENTS WITH CHRONIC GASTRITIS IN HIGH INCIDENCE AREA OF STOMACH CANCER

作　　者：谢同欣[1] 张祥宏[1] 王凤荣[1] 孙玉敏[2] 张振东[1] 

机构地区：[1]河北医学院基础所病理室 [2]河北省肿瘤研究所

出　　处：《肿瘤》1990年第1期4-6,共3页Tumor

摘　　要：我国有学者曾对国内六个胃癌高发区进行了病因流行病学调查,发现这些地区的慢性胃病患者胃液中杂色曲霉的检出率最高。河北省赞皇县是胃癌高发区,胃癌年平均死亡率为59/10万。我们用小鼠微核试验和人外周血淋巴细胞程序外DNA合成(UDS)试验的方法。The Aspergillus versicolor was separated from gastric juice of patients with chronicgastritis in Zanhuang County in Hebei Province, which is a high incidence area forstomach cancer. From A. versicolor culture an extract was prepared. After subcutaneousinjection of the extract into NIH mice, the micronucleus rate in blood lymphocyteswas greater than that in control group (P<0.01). Human peripheral blood lymphoctes(including monocytes) were treated in vitro with the extract at different dosages andthe resulted values of unscheduled DNA synthesis were much higher than that in controlgroup (P<0.01). The results suggest that the extract of A. versicolor is mutagenic orcarcinogenic and may play some role in the genesis of human stomach cancer.

关 键 词：胃肿瘤 胃液 杂色曲霉 遗传病毒 

分 类 号：R735.202[医药卫生—肿瘤]