胃癌细胞外基质与癌分化、浸润和转移的关系  

IMMUNOHISTOCHEMICAL STUDY OF THE EXTRACELLULAR MATRIX OF GASTRIC ADENOCARCINOMA IN RELATION TO DIFFERENTIATION,INVASION AND METASTASIS

作　　者：李一伟[1] 沈云英[1] 

机构地区：[1]福建医学院病解教研室

出　　处：《肿瘤》1990年第4期153-154,共2页Tumor

摘　　要：细胞外基质包括基底膜和间隙基质,在决定组织结构、细胞粘附、细胞分化和分裂等方面起重要作用。国外研究发现,基底膜成分在浸润性肿瘤中不同程度地丧失,层粘连蛋白和纤维联接蛋白影响恶性瘤细胞的浸润性移动。本文通过研究非癌胃粘膜和胃癌细胞外基质成分—Ⅳ型胶原蛋白(Type Ⅳ collagen)、层粘连蛋白(Laminin)及纤维联接蛋白(Fibronectin)的变化,探讨胃癌细胞外基质与肿瘤分化、浸润和转移的关系。By using the immunohistochemical techniques, extracellular matrix of 45 cases ofgastric adenocarcinoma and 25 cases of noncancerous stomach were studied in thepurpose of analyzing their role in differentiation invasion and metastasis of the tumor.Four different primary antibodies against laminin type Ⅳ collagen and fibronectinwere used to localize and to estimate quantitatively the different components of extra-cellular matrix. The results showed: 1.Type Ⅳ collagen and laminin were lost in variousamount in accordance with the degree of tumor differentiation. 2.More amount offibronectin was detected in the stroma of the gastric adenocarcinoma with metastasis.

关 键 词：胃癌 分化 浸润 转移 

分 类 号：R735.202[医药卫生—肿瘤]