血浆血栓调节蛋白和血管性血友病因子测定在急性缺血性结肠炎诊治中的研究  

Study of the plasma thrombomodulin and von Willebrand factor determination in the diagnosis and treatment of acute ischemic colitis

作　　者：金伟[1] 周洪美[1] 董涛[1] 李永柱[1] 赵存新[1] 张银华[1] 

机构地区：[1]山东省潍坊市益都中心医院消化内科,山东青州262500

出　　处：《中国医师进修杂志》2012年第25期18-20,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血浆血栓调节蛋白（TM）、血管性血友病因子（vWF）水平变化与急性缺血性结肠炎的病变范围及病情轻重的关系。方法采用酶联免疫吸附法分别测定46例急性缺血性结肠炎患者（急性缺血性结肠炎组）、42例溃疡性结肠炎患者（溃疡性结肠炎组）、40例健康体检者（对照组）血浆TM、vWF水平。结果急性缺血性结肠炎组血浆TM（49．64±2．3）μg/L、vWF（198．84±8．9）％；溃疡性结肠炎组血浆TM（38．2±3．8）μg／L、vWF（162．6±7．6）％；对照组血浆TM（23．84±2．3）μg／L、vWF（116．7±6．2）％；急性缺血性结肠炎组血浆TM、vWF水平显著高于溃疡性结肠炎组及对照组，差异有统计学意义（P〈0．05或〈O．01）；溃疡性结肠炎组血浆TM、vWF水平显著高于对照组，差异有统计学意义（P〈0．05）。急性缺血性结肠炎组全结肠病变患者血浆TM、vwF水平[（49．94±0．3）μg／L、（210．64±8．2）％]显著高于其他病变部位患者，差异有统计学意义（P〈0．05）。结论急性缺血性结肠炎患者均存在不同程度的凝血和纤溶系统的激活，联合检测血浆TM、vWF水平可作为急性缺血性结肠炎病情进展、预后判定的指标之一。Objective To study the changes of the plasma thrombomodulin （TM） and von Willebrand factor （vWF） levels and their clinical significance associated with the extent and severity of acute ischemic colitis. Methods The plasma TM and vWF levels were determined by enzyme linked immunosorbent assay in 46 patients with acute ischemic colitis （acute ischemic colitis group）, 42 patients with ulcerative colitis （ulcerative colitis group） and 40 healthy subjects （control group）. Results The plasma TM was （49.6 ± 2.3 ） μg/L, and vWF was （198.8 ± 8.9）% in acute ischemic colitis group. The plasma TM was （38.2 ± 3.8 ） μg/L, and vWF was （ 162.6 ± 7.6 ）% in ulcerative colitis group. The plasma TM was （23.8 ± 2.3 ） μg/L, and vWF was （ 116.7 ± 6.2 ）% in control group. The plasma TM and vWF levels in acute isehemic colitis group were higher than those in ulcerative colitis group and control group （P 〈 0.05 or 〈 0.01 ）. The plasma TM and vWF levels in ulcerative colitis group were higher than those in control group （P 〈 0.05 ）. The plasma TM levels [ （49.9 ± 0.3 ） μg/L] and vWF [ （210.6 ± 8.2 ） % ] in all colon disease were higher than those in partial colon disease （P 〈 0.05 ）. Conclusion The changes of plasma TM and vWF levels can be used as one of the indicators for assessment of the development and the prognosis of acute ischemic colitis.

关 键 词：结肠炎 缺血性 血栓调节蛋白 yon WILLEBRAND因子 

分 类 号：R574.62[医药卫生—消化系统]