苯甲醛、2-异丁腈与丙二酸二乙酯的三组分Passerini反应  

Three components Passerini reactions of Benzaldehyde, 2-Isobutyronitrile and Diethyl Malonate

作　　者：陈懿[1] 谢兵[1] 高斌[1] 

机构地区：[1]贵州民族大学化学与环境科学学院,贵州贵阳550025

出　　处：《贵州师范学院学报》2012年第6期28-30,共3页Journal of Guizhou Education University

基　　金：贵州省科技厅基金项目;项目合同编号:LKM[2011]26号

摘　　要：探索用丙二酸二乙酯替代羧酸或醇进行三组分Passerini反应。在无溶剂条件下,用浓硫酸作为催化剂,苯甲醛、2-异丁腈和丙二酸二乙酯通过微波辅助和加热,一锅法进行三组分Passerini反应,以中等收率得到具有重要应用价值的双官能团化合物丙二酸二乙酯衍生物。该反应的最佳条件为:以浓硫酸为催化剂,催化剂用量为2 mL,反应温度为120℃,微波功率为300 W,反应时间为40 min。The paper explores three multieomponent Passerini reactions by using diethyl malonate instead of car- boxylic acid or alcohol. The significant applied value of compounds including double functional group diethyl malonate derivative from benzaldehyde, 2 - isobutyrenitrile and diethyl malonate was synthesized by one - pot in moderate yield by using H2SO4 as catalyst at microwave and heat under free - solvent. The optimized reaction condition follows the aspects： 2mL H2SO4 as catalyst; reaction temperature was 120 ℃, power rating for micrwave was 300 W and reaction time was 40 min.

关 键 词：三组分Passerini反应 一锅法 丙二酸二乙酯衍生物 微波辅助 无溶剂反应 

分 类 号：O621.3[理学—有机化学]