滋养细胞肿瘤患者及其配偶的姐妹染色单体互换和核仁组织区活性研究  

THE STUDY OF TROPHOBLASTICS VERSUS THEIR SPOUSES ON SISTER CHROMATID EXCHANGE AND THE ACTIVITY OF NUCLEOLAR ORGANIZER REGIONS

作　　者：舒静[1] 张蕴璟[1] 王秉正[1] 

机构地区：[1]西安医科大学第一附属医院妇产科

出　　处：《肿瘤防治研究》1990年第4期231-236,共6页Cancer Research on Prevention and Treatment

摘　　要：本文对良性葡萄胎,恶性葡萄胎及绒毛膜癌患者和配偶同时进行了姐妹染色单体互换(SCE)及核仁组织区(NOR)活性研究。结果表明,恶葡和绒癌的发病可能与患者固有的DNA修复能力缺陷和DNA损伤有关;滋养细胞肿瘤的发生可能与患者具有的潜在的可被激活的NOR活性无关。虽然滋养细胞肿瘤的发病与受孕有密切的关系,但对配偶的SCE及NOR活性两方面的研究,未发现患者配偶的遗传物质整体水平特性与该肿瘤发病的关系。The artical described the study of chromosome in patients with benign mole, malignant mole and choriocarcinoma yersus their spouses on sister chromatid exchange and the activity of nucleolar organizer regions (NOR).The results suggested that the pathogenecity of malignant mole and choriocarcinoma might be associated withpatient's abnormal ability of DNA repair and damage of DNA. The potential and activable NOR might have no relation to the tumors. Although the patient's spouses might play a role in the occurrence of the trophoblastic tumors, the retults excluded the property of the genetic matehial of the spouses in connection with the occurrence of the tumors on SCE and the a ctivity of NOR.

关 键 词：滋养细胞肿瘤 SCE NOR DNA 

分 类 号：R737.33[医药卫生—肿瘤]