吲哚菁绿清除试验和终末期肝病模型评分  

Indocyanine green clearance test and model for end-stage liver disease scores

作　　者：胡峰[1] 王中峰[1] 王伟[1] 张洪[1] 高普均[1] 

机构地区：[1]吉林大学第一医院肝胆胰内科,长春130021

出　　处：《肝脏》2012年第8期551-553,共3页Chinese Hepatology

基　　金：吴阶平医学基金会肝病医学部肝功能评估研究基金资助项目(LDWMF-PJ-2011D001)

摘　　要：目的探讨吲哚菁绿(ICG)清除试验与4种终末期肝病模型评分(MELD、MELD-Na、MESO、iMELD)之间的关系。方法 70例失代偿期肝硬化患者行ICG清除试验检测15分钟滞留率(R15)和血浆清除率(K);同时计算患者MELD、MELD-Na、MESO和iMELD评分,采用Spearman等级相关性分级及LSD检验,比较ICGR15、K值与MELD、MELD-Na、MESO和iMELD评分之间的关系。结果随着Child-Pugh分级的升高,R15、MELD、MELD-Na、MESO、iMELD评分升高,K值降低。R15与MELD、MELD-Na、MESO、iMELD呈正相关(r=0.59、0.56、0.61、0.63,P<0.05),K值与MELD、MELD-Na、MESO、iMELD评分呈负相关(r=-0.55、-0.53、-0.58、-0.59,均P<0.05)。结论 R15和K值与MELD、MELD-Na、MESO、iMELD评分关系密切;R15与4种终末期肝病模型评分相关性比K值显著,其中R15与iMELD相关性更加显著。Objective To investigate the correlation among indocyanine green （ICG） clearance test and model for end-stage liver disease scores including MELI）, MEI.D-Na, MESO and iMELD scores. Methods Seventy patients with decompensated liver cirrhosis were selected. The ICG clearance test （K value and R15） was performed,and the MELD, MELD-Na,MESO,iMEI.D scores of patients with decompensated liver cirrhosis were calculated. Results As the Child- Pugh classification of liver function gradually deteriorated, R15 and MELD, MELD-Na, MESO,iMELD scores increased, while K value decreased, significant statistical differences in K value, R15, MELD, MELD-Na, MESO, iMELD scores were found between patients with different Child-Pugh classifications. Significant correlations were found among the parameters of the ICG clearance test （K value and R15）） and MELD, MELD-Na, MESO,iMELD scores. The positive correlation was observed among R15 and MEI.D, MELD-Na,MESO,iMELD scores（r = 0.59,0. 56, 0. 61,0.63;P〈0.05）, while the negtive correlation were observed among K value and MELD, MELIYNa, MESO,iMELD scores（r = -0.55 ,-0.53, -0.58, -0.59;P〈0. 05）. Conclusion K value and R15 have significant correlation with MELD, MELD-Na, MESO, iMELD score,especially the R15, and R15 has the best significant correlation with iMEI.D in four model for end-stage liver disease scores, which may be convenient and appropriate indicator to evaluate liver function of patients with decompensated liver cirrhosis, and better than MELD score.

关 键 词：吲哚菁绿 排泄试验 终末期肝病模型 肝脏储备功能 

分 类 号：R575.2[医药卫生—消化系统]