艾蒿黄酮对低剂量X-射线辐射损伤小鼠的防护作用  

Protective effect of flavonoids of Artemisia argyi on low-level X-ray irradiated mice

作　　者：孙锋[1] 陈子海[1] 

机构地区：[1]安徽农业大学生命科学学院,安徽合肥230036

出　　处：《食品工业科技》2012年第18期341-343,共3页Science and Technology of Food Industry

基　　金：国家自然科学基金(31000314)

摘　　要：目的:研究艾蒿黄酮对低量X-射线辐射小鼠的白细胞和主要器官的防护作用。方法:将小白鼠随机分为5组,正常对照组、辐射对照组、低剂量药物组(30mg/kg)、中剂量药物组(60mg/kg)和高剂量药物组(90mg/kg)。每组20只,均灌胃给药,每只小鼠1mL/次,2次/d(早晚各一次)。以1.0Gy的X-射线辐射处理,每次210s,连续15d。对体重、血液中白细胞以及各主要器官的SOD、MDA检测。结果:中剂量组的各项检测指标与正常对照组相比差异不大,与辐射对照差异显著。结论:一定剂量的艾蒿黄酮能抑制X射线给机体的白细胞以及各主要器官带来的损伤和毒害作用。Objective：To study protective effect of argyi wormwood flavonoids on WBC and major organs of X-ray irradiated mice.Methods：Mice were randomly divided into 5 groups,normal control group,radiation control group,low-dose group（30mg/kg）,medium-dose group（60mg/kg）,high-dose group（90mg/kg）.20 mice in each group,every mice were gavaged twice a day（morning and evening）,2mL each time.The mice were irradiated 210s every time for 15 days by 1.0Gy X-ray.The body weight,WBC were determined and the activities of SOD,MDA in major organs were assayed respectively.Results：The detection of indicators of medium-dose group were little difference copared with normal control group,but significant difference copared with radiation control group.Conclusion：It was showed that a certain dose of wormwood flavonoids could inhibit damage and toxic to WBC and major organ by X-ray irradiated.

关 键 词：艾蒿黄酮 X-射线 白细胞 SOD MDA 抗氧化 

分 类 号：R979.6[医药卫生—药品]