不同级别卵巢浆液性癌中E-cadherin和p120蛋白的表达及意义  

The expressions of E-cadherin,p120 protein in different grades of ovarian serous carcinoma and its significance

作　　者：陈丽倩[1,2] 林洁[1,2] 席晨光[1,2] 刘从容[1,2] 

机构地区：[1]北京大学医学部病理学系 [2]北京大学第三医院病理科,北京100191

出　　处：《现代妇产科进展》2012年第8期585-589,共5页Progress in Obstetrics and Gynecology

基　　金：北京市自然科学基金(No:7082055);归国留学人员启动基金[No:教外司留(2008)890];迈新基金(迈新基金管理委员会No:m0902);73项目子课题(No:2009CB521805)

摘　　要：目的:探讨上皮性钙黏附蛋白(E-cadherin)和连环蛋白p120在不同组织学级别卵巢浆液性癌中的表达及意义。方法:用免疫组化EnVision二步法,分别检测31例卵巢低级别浆液性癌和70例卵巢高级别浆液性癌中E-cadherin和p120蛋白的表达水平,分析其与卵巢浆液性癌临床病理资料的相关性。结果:E-cadherin在低级别浆液性癌和高级别浆液性癌中的阳性率分别为71.0%和61.4%(P=0.356);p120的阳性率分别为83.9%和60.0%(P=0.018)。高级别浆液性癌中,E-cadherin和p120蛋白表达率随着FIGO分期(P=0.015和P=0.011)、淋巴结转移(P=0.001和P=0.001)及大网膜受累(P=0.028和P=0.018)显著降低。E-cadherin蛋白表达率随年龄增高显著降低(P=0.011),而p120蛋白表达率与年龄无显著相关性(P=0.226)。低级别浆液性癌中,仅p120蛋白表达率与淋巴结转移(P=0.042)、大网膜受累(P=0.048)及术前CA125水平(P=0.042)具有显著相关性。结论:卵巢高级别浆液性癌中p120蛋白的表达缺失率显著高于卵巢低级别浆液性癌,同时仅在高级别浆液性癌中E-cadherin和p120的低表达均与FIGO分期和肿瘤转移潜能相关,提示E-cadherin和p120蛋白可能在不同级别卵巢浆液性癌的发生发展中具有不同的作用。Objective：To investigate the expressions and its significances of E-cadherin and p120 catenin（p120） in serous ovarian carcinoma.Methods：Using immunohistochemical technique,the expressions of E-cadherin and p120 in 31 cases of low-grade ovarian serous carcinoma and 70 cases of high-grade ovarian serous carcinoma were examined.Their relationship with clinicopathological data was analyzed.Results：The positive expression rates of E-cadherin in low-grade and high-grade serous carcinoma were 71.0% and 61.4% respectively（P=0.356）.The positive expression rates of p120 in low-grade and high-grade serous carcinoma were 83.9% and 60.0% respectively（P=0.018）.In the group of high-grade serous carcinoma,the expressions of E-cadherin and p120 were significantly correlated with FIGO staging（P=0.015,P=0.011）,lymph node metastasis（P=0.001,P=0.001） and invaded omentum（P=0.028,P=0.018）.E-cadherin expression was correlated with age（P=0.011） while p120 was not（P=0.226）.In the group of low-grade serous carcinoma,only the expression level of p120 showed significant association with lymph node metastasis（P=0.042）,invaded omentum（P=0.048） and preoperative CA125 level（P=0.042）.Conclusion：Expression of p120 protein in high-grade serous ovarian carcinoma is significantly reduced.And only in high-grade serous ovarian carcinoma,loss of E-cadherin and p120 expression are correlated with FIGO staging,invasion and tumor metastasis,suggesting that E-cadherin and p120 may have different functions in the development of different types of ovarian serous carcinoma.

关 键 词：卵巢肿瘤 肿瘤 浆液性 免疫组织化学 钙黏着糖蛋白类 E-钙黏蛋白 连环蛋白 P120 

分 类 号：R737.31[医药卫生—肿瘤]