慢性酒精中毒患者血清中tau蛋白、Aβ_(1-42)的测定及临床意义  

Clinical significance of detecting serum Tau protein and Aβ_(1-42) in patient with chronic alcoholism

作　　者：鲁艺花[1] 崔松彪[1] 吴光[1] 

机构地区：[1]延边大学附属医院神经内科,吉林延吉133000

出　　处：《中风与神经疾病杂志》2012年第8期740-743,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的研究酒精中毒患者血清tau蛋白及Aβ1-42测定的临床意义及其参与酒精致神经系统损害的机制。方法 40名慢性酒精中毒患者(饮酒时间均超过5年)按饮酒年限分为饮酒20年以上组及20年以下组。按头部CT结果分为脑萎缩组及无脑萎缩组。用ELISA方法测定40名酒精中毒患者及16名健康人的血清tau蛋白及Aβ1-42水平。结果 (1)慢性酒精中毒患者血清tau蛋白高于正常对照组,但两者之间无统计学意义。脑萎缩组血清tau蛋白水平显著高于无脑萎缩组及正常对照组,差异具有统计学意义(P<0.05)。饮酒20年以上组血清tau蛋白显著高于饮酒20年以下组以及正常对照组,差异有统计学意义(P<0.05)。(2)慢性酒精中毒患者血清Aβ1-42明显高于正常对照组,有统计学意义(P<0.01)。脑萎缩组及无脑萎缩组血清Aβ1-42均明显高于正常对照组,且有统计学意义(P<0.01)。饮酒20年以上组及饮酒20年以下组血清Aβ1-42均明显高于正常对照组,且有统计学意义(P<0.01)。结论 (1)慢性酒精中毒患者血清tau蛋白、Aβ1-42增高,可能对慢性酒精中毒的诊断有意义。(2)tau蛋白、Aβ1-42可能参与酒精致神经系统损害的机制。Objective To explore the clinical significance of detecting the serum tau protein and Aβ1-42 in patient with chronic alcoholism and investigate the mechanism of learning and memory disorder induced by alcoholism.Methods 40 patients with chronic alcoholism and 16 healthy controls were selected.All the patients had the history of drinking more than 5 years,and they were divided into 5～20 years group and more than 20 years group.According to CT,the patients were divided into encephalatrophy group and normal group.ELISA was used to measure serum Tau protein and Aβ1-42.Results The serum Tau protein in patient with chronic alcoholism was higher than that of control group.But there was no significance.The serum tau protein in patient with encephalatrophy group was significantly higher than that of CT normal group and control group（P0.05）.The serum tau protein in driking for more than 20 years group was significantly higher than that of 5～20 years group and control group（P0.05）.The serum Aβ1-42 level in patient with chronic alcoholism was significantly higher than that of control group.The serum Aβ1-42 level in encephalatrophy group and CT normal group were significantly higher than that of control group（P0.01）.The serum Aβ1-42 level in driking for more than 20 years group and 5～20 years group was significantly higher than that of control group（P0.01）.Conclusion The serum tau protein and Aβ1-42 level may be a potential biomarker for chronic alcoholism.Serum Tau protein and Aβ1-42 may be involved in neurological damage induced by alcoholism.And serum tau protein may be related with the degree of brain damage.

关 键 词：慢性酒精中毒 TAU蛋白 AΒ1-42 

分 类 号：R742[医药卫生—神经病学与精神病学]