改良CHOP方案治疗初治低Karnofsky评分非霍奇金淋巴瘤患者的临床观察  

Clinical observation of modified CHOP regimen in the initial treatment of non-Hodgkin＇ s lymphoma patients with low Karnofsky score

作　　者：李涛[1] 吴祥成[1] 凌华晃[1] 黄锡梅[1] 吴非常[1] 苏炳光[1] 

机构地区：[1]广东省高州市人民医院化疗科,525200

出　　处：《白血病．淋巴瘤》2012年第8期475-476,480,共3页Journal of Leukemia & Lymphoma

摘　　要：目的观察改良CHOP方案治疗初治低Karnofsky评分非霍奇金淋巴瘤（NHL）患者的疗效。方法将20例初治低Karnofsky评分NHL患者随机分成治疗组和对照组，分别采用改良和标准CHOP方案进行治疗。结果经1个周期治疗后，治疗组13例中12例Karnofsky评分〉60分，1例仍〈60分，总有效率92．3％（12／13）；对照组7例患者中，3例Kamofsky评分〉60分，4例仍〈60分，总有效率100．0％（7／7），对照组骨髓不良反应发生率为57．1％（4／7），两组间总有效率差异无统计学意义（P=0．4515），患者Karnofsky评分改善差异有统计学意义（P=0．0149）。结论改良CHOP方案治疗初治的低Karnofsky评分NHL患者可以改善其Karnofsky评分，有利于患者的后期治疗和降低住院费用。Objective To observe the effecacy of modified CHOP regimen in the initial treatment of non-Hodgkin＇ s lymphoma （NHL） patients with low Karnofsky score. Methods Twenty initial treatment NHL patients with low Kamofsky score were randomly allocated into treatment group and control group,respectively treated with modified and standard CHOP regimen. Results Of 13 cases in treatment group, 12 patients＇ Karnofsky score were over 60, 1 was still below 60, overall response （OR） rate was 92.3 % （12/13）, while in control group, 3 patients＇ Karnofsky score were over 60, 4 were still below 60, OR rate was 100 % （7/7）, rate of marrow toxicity was 57.1% （4/7）. There were no significantly difference for OR rates （P = 0.4515）, but for improving Karnofsky score there were significantly difference （P = 0.0149）. Conclusion Modified CHOP regimen can improve Karnofsky score of NHL patients with low Karnofsky score, benefical for further treatment and reducing hospitalization cost.

关 键 词：淋巴瘤 非霍奇金 抗肿瘤联合化疗方案 Karnofsky 

分 类 号：R733.1[医药卫生—肿瘤]