初步观察早期盲人静息状态下的局部脑活动  

Regional brain activity in early blind during resting state:A pilot observation

作　　者：李伟兰[1] 刘勇[2] 秦文[1] 蒋田仔[2] 于春水[1,3] 

机构地区：[1]天津医科大学总医院放射科,天津300052 [2]中国科学院自动化所模式识别国家重点实验室LIAMA计算医学研究中心,北京100039 [3]首都医科大学宣武医院放射科,北京100053

出　　处：《中国医学影像技术》2012年第9期1627-1631,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的比较早期盲人(EB)与正常人之间脑低频振幅(ALFF)及活动幅度(AM)的差异,观察EB静息状态下的局部脑活动变化。方法利用3.0T MR对16例EB(EB组)和32名性别、年龄相匹配的正常志愿者(NC组)行静息态fMRI数据采集。采用SPM8软件进行图像预处理,通过基于体素的分析比较两组间未标准化和标准化ALFF值的差异,并进一步比较标准化ALFF存在显著差异脑区的AM值。结果与NC组相比,EB组未标准化ALFF值呈显著性增高的脑区主要位于双侧枕中回、枕下回、舌回、梭状回、距状沟皮质及颞下回;标准化ALFF值呈显著增高的脑区与未标准化ALFF值呈显著性增高的脑区基本一致;EB组上述脑区的AM值显著高于NC组。结论 EB静息状态下枕叶皮层活动增高,可能与皮层发育和可塑性有关。Objective To identify changes of regional brain activity in early blind （EB） under resting state by comparing the amplitude of low frequency fluctuation （ALFF） and activity amplitude （AM） between EB group and normal control group （NC group）. Methods Resting state fMRI was performed in 16 EB （EB group） and 32 age- and gender-matched （NC group） using a 3.0T MR scanner. SPM8 software was used for image preprocessing. Voxel-based analysis was performed to identify brain areas with significant changes in unnormalized and normalized ALFF values between the two groups. Then AM values were compared between the two groups in brain areas with significant differences in ALFF. Results Compared with NC group, EB group showed increased ALFF in visual-related areas including the bilateral middle and inferior occipital gyri, lingual and fusiform gyri, calcarine cortices, and inferior temporal gyri. Intergroup differences were present in both the unnormalized and normalized ALFF analyses. The AM values of these visual-related areas were significant higher in EB group than those in the NC group. Conclusion Both the developmental mechanism and plasticity mechanism may contribute to the higher resting state brain activity in the visual-related areas in EB.

关 键 词：磁共振成像 大脑皮质 低频振幅 静息态 早期盲人 

分 类 号：R77[医药卫生—眼科] R445.2[医药卫生—临床医学]