胃黏膜相关淋巴组织淋巴瘤中环氧化酶－2和CD97的表达与预后的关系  

Expression of COX-2 and CD97 in gastric mucosa-associated lymphoid tissue lymphomas

作　　者：程骏[1] 张培趁[1] 徐晓琼[1] 韩少良[1] 吴秀玲[2] 朱冠保[1] 

机构地区：[1]温州医学院附属第一医院胃肠外科,325000 [2]温州医学院附属第一医院病理科,325000

出　　处：《浙江医学》2012年第16期1322-1325,1358,共5页Zhejiang Medical Journal

基　　金：温州市科技局资助项目（Y20090063）

摘　　要：目的探讨环氧化酶2（COX-2）和CD97在胃黏膜相关淋巴组织（MALT）淋巴瘤中的表达及与预后的关系。方法采用Envision二步法对47例胃MALT淋巴瘤进行COX-2和CD97免疫组化染色，并对其幽门螺杆菌（Hp）感染、肿瘤临床分期、浸润深度、肿瘤大小、复发率、化疗和放疗情况等指标作单因素和多因素COX回归分析。结果（1）肿瘤的COX-2及CD97阳性表达率分别为48．9％及87．2％，它们的表达与肿瘤临床病理分期、浸润深度、肿瘤大小明显相关（均P〈005），COX-2的表达还与Hp感染有关（P〈0．01）；（2）生存分析显示，COX-2阳性患者的平均生存时间（59．9个月）短于阴性患者（77．8个月），但两组间的差异无统计学意义（P〉O05）；CD97强阳性患者平均生存时间392个月，显著短于非强阳性患者的100．3个月（P〈0．01）。肿瘤临床病理分期是胃MALT淋巴瘤预后的独立危险因素（风险度为3．041，回归系数为1．112，形以d统计量为13．985，P〈0．01），且与预后呈负相关；而COX-2和CD97均不是影响预后的独立危险因素。结论COX-2和CD97的表达水平与肿瘤进展密切相关，Hp感染可上调COX-2的表达。Objective To investigate the expression of cyclooxygenase-2 （COX-2） and CD97 protein in gastric mucosa-associated lymphoid tissue （MALT） lymphomas and its clinical significance. Methods The expressions of COX-2 and CD97 in 47 cases of gastric MALT lymphoma were examined by immunohistochemistry （Envision two-step method）. The associations of prognosis with Hp infection, clinical stage, invasion depth, tumor size, recurrent rate, treatment modalities and ex- pression of COX-2 and CD97 were analyzed by univariate and multivariate COX regression model. Results The expressions rates of COX-2 and CD97 in gastric MALT lymphoma were 48.9% and 87.2% respectively, which were positively correlated with clinical stage, invasion depth and tumor size （P〈0.05）. Moreover, COX-2 expression was correlated with Hp infection （P〈0.01）. Univariate analysis showed that there was no significant difference in overall survival of gastric MALT lymphoma patients between those with positive and negative COX-2 expression （59.9 vs 77.8 months, P 〉0.05）. The survival was significantly shorter in pa- tients with strong expression of CD97 protein than those with moderate expression （100,3 vs 39.2 months, P〈0.01）. Multivariate COX regression analysis revealed that clinicopathological stage was independent prognostic factor and associated with short survival. Conclusion COX-2 and CD97 expressions may be associated with the development of gastric MALT lymphoma. Up-regulated expression of COX-2 is associated with Hp infection. The strong expression of CD97 is predictors of poor survival in patients with gastric MALT lymphoma.

关 键 词：胃肿瘤 黏膜相关淋巴瘤 COX-2 CD97预后 

分 类 号：R735.2[医药卫生—肿瘤]