游离脂肪酸与非酒精性脂肪性肝病的相关性  

Correlation between serum free fatty acid and nonalcoholic fatty liver disease

作　　者：汪明东[1] 孙立山[1] 郑慧雅[1] 陆柳[1] 范列英[1] 

机构地区：[1]同济大学附属东方医院检验科,上海200120

出　　处：《同济大学学报（医学版）》2012年第4期54-56,82,共4页Journal of Tongji University(Medical Science)

摘　　要：目的探讨游离脂肪酸(free fatty acid,FFA)与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)发病的相关性。方法分别测定296例NAFLD患者和189例健康对照个体血清中的FFA、空腹血糖(fasting blood glucose,FBG)、三酰甘油(triglyceride,TG)、总胆固醇(cholesterol,CHOL)、高密度脂蛋白胆固醇(highdensity lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)等指标。结果NAFLD组血清FFA水平显著高于对照组[(0.82±0.39)]mmol/L,(0.38±0.17)mmol/L,P<0.01)]。Pearson相关分析提示血清FFA水平与TG,GLU,CHOL,LDL-C存在明显的正相关,与HDL-C存在明显的负相关。结论血清FFA水平与NAFLD患病显著相关,并且与TG,GLU,CHOL等指标相关。Objective To explore the correlation between serum free fatty acid （FFA） and nonalcoholic fatty liver disease （NAFLD）. Methods FFA, fasting blood glucose （FBG）, triglyceride （ TG ）, total cholesterol （ CHOL ）, high density lipoprotein cholesterol （ HDL-C ）, low density lipoprotein cholesterol （LDL-C）, were measured in serum samples from 296 patients with NAFLD and 189 sex- and age-matched subjects （control group）. Results Serum FFA levels were higher in NAFLD patients than those in controls [ （0.82 ±0.39） mmol/L vs. （0.38 ±0.17） mmol/ L, P 〈 0.01 ） 1. Serum FFA was positively correlated with TG, GLU, CHOL, LDL-C, while it was negatively correlated with HDL-C in pearson correlation analysis. Conclusion Serum FFA levels are significantly associated with NAFLD, and associated with triglycerides, glucose and total cholesterol levels.

关 键 词：游离脂肪酸 非酒精性脂肪性肝病 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]