Efficient Synthesis of 3-Methyl-flavanones and Evaluation of Their Anti-bacterial Activity  

作　　者：Nawghare Beena Funde Sharad Raheem Abdul Lokhande Pradeep 

机构地区：[1]The Centre for Advanced Studies, Department of Chemistry, University of Pune, Pune 411 007, India

出　　处：《Chinese Journal of Chemistry》2012年第8期1695-1698,共4页中国化学（英文版）

摘　　要：A series of 2-phenyl-2,3-dihydrochromon-4-one derivatives （flavanone derivatives） were synthesized by silica gel assisted isomerization of several a-methyl-2＇-hydroxy chalcones in 74%--88% yield. These flavanones were further oxidized to 3-methyl flavones by using iodine in dimethyl sulphoxide at 60℃ in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus, Micrococcus luteus and Staphylococcus epidermis.A series of 2-phenyl-2,3-dihydrochromon-4-one derivatives （flavanone derivatives） were synthesized by silica gel assisted isomerization of several a-methyl-2＇-hydroxy chalcones in 74%--88% yield. These flavanones were further oxidized to 3-methyl flavones by using iodine in dimethyl sulphoxide at 60℃ in presence of acid. The newly synthesized derivatives were evaluated for in vitro study against Staphylococcus aureus, Micrococcus luteus and Staphylococcus epidermis.

关 键 词：CYCLIZATION OXIDATION CHALCONES silica gel 3-methyl-flavanones 

分 类 号：TQ252.4[化学工程—有机化工] S782.33[农业科学—木材科学与技术]