青年人大肠癌影响因素病例对照研究  

Risk factors of colorectal cancer among young people:a case-control study

作　　者：刘桃成[1] 廖嫦英[2] 梁维君[1] 吕媛[1] 钟贵良[1] 

机构地区：[1]湖南师范大学医学院流行病与卫生统计教研室,湖南长沙410013 [2]湖南省肿瘤医院

出　　处：《中国公共卫生》2012年第9期1144-1146,共3页Chinese Journal of Public Health

基　　金：湖南省教育厅科研基金(05C398)

摘　　要：目的初步探讨青年人(≤35岁)大肠癌发病的危险因素,为进一步研究提供科学依据。方法以湖南省肿瘤医院确诊的大肠癌患者为病例组,运用1:1匹配病例对照研究方法,用条件logistic回归对青年人大肠癌相关变量进行单因素和多因素分析。结果病例组、对照组男性均为88例,女性均为64例;病例组年龄为16～35岁,平均年龄为(28.62±3.56)岁,对照组年龄为17～37岁,平均年龄为(30.27±2.84)岁,2组年龄差异无统计学意义;病例按病变部位分为直肠73例,结肠79例;病理类型为腺癌86例,黏液腺癌38例,印戒细胞癌17例,未分化癌11例;多因素分析结果表明,肠息肉、直系亲属癌症史、慢性肠炎、精神刺激史、常吃动物油及动物食品为青年人大肠癌的危险因素(OR=8.752、6.370、5.249、5.016、3.458、2.967),经常锻炼、常吃蔬菜为其保护性因素(OR=0.384、0.650)。结论肠息肉、直系亲属癌症史、慢性肠炎、精神刺激史、常吃动物油及动物食品可能是中国青年人大肠癌的危险因素,而经常锻炼和常吃蔬菜可能是其保护因素。Objective To explore risk factors of colorectal cancer among young Chinese people and to provide ref- erence for further research. Methods A hospital-based 1：1 matched case-control study was conducted among young patients aged ≤35 years with colorectal cancer. Conditional logistic regression model was used for univariate and multivariate analyses. Results The number of male pairs was 88 and that of female pairs was 64. The average age of cases was 28.62 ± 3.56 years and that of controls was 30. 27 ± 2. 84 years, without significant difference. The anatomic type of the cases included rectum cancer（ 73 ） and colon cancer（79） and the pathologic type included adenocarcinoma（ 86）, mucinous adenocarcinoma（38） ,signet ring cell cancer（ 17 ） , and undifferentiated carcinoma（ 11 ）. The results of multivariate analyses showed that the odds ratios of bowel polyps, immediate family history of cancer, chronic colorectitis, psychic attack,eating animal oil frequently, and eating animal foods frequently were 8. 752,6. 370,5. 249,5. 016,3. 458 and 2. 967 ,respectively. The odds ratios of taking exercise frequently and eating vegetable frequently were 0. 384 and 0. 650. Conclusion Bowel polyps, immediate family history of cancer, chronic colorectitis, psychic attack, eating animal oil frequently, and eating animal foods frequently may be the risk factors of colorectal cancer, while taking exercise frequently and eating vegetable frequently may be the protective factors among young Chinese people.

关 键 词：大肠癌 青年人 危险因素 病例对照研究 

分 类 号：R730.231[医药卫生—肿瘤]