中国人群TGF-α基因TaqⅠ位点多态性与非综合征性唇腭裂相关性的Meta分析  

Association between TGF-α TaqⅠpolymorphism and risk of NSCL/P:a meta-analysis

作　　者：张玉[1] 杨梅[1] 仇君[1] 刘伟[1] 张康[1] 杜玉开[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院,武汉430030

出　　处：《中国优生与遗传杂志》2012年第8期11-14,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨TGF-α基因TaqⅠ位点多态性与中国人群非综合征性唇腭裂的相关性。方法以非综合征性唇腭裂患者与对照组TGF-α基因TaqⅠ位点等位基因及基因型分布的OR值为效应指标,通过检索中国学术文献总库、维普、万方以及MEDLINE,PubMed,EMBASE等数据库中的相关文献,使用STATA10.0对各研究进行异质性检验和效应值合并,进行发表偏倚和敏感性分析。结果最终纳入11篇病例对照(病例亲本)研究,其中病例组1177例,对照组1293例。以等位基因C1以及基因型C1C1为参照,提示在TGF-α基因TaqⅠ位点中携带等位基因C2与非综合征性唇腭裂发病显著相关,携带C1C2或C2C2基因型的个体发生NSCL/P的风险增加(OR=2.00,95%CI:1.63～2.46)。结论在中国人群中,TGF-α基因TaqⅠ位点携带C1C2或C2C2基因型可能是非综合征性唇腭裂发病的危险因素。Objective： To explore whether transforming growth factor αTaq I polymorphism is associated with NSCL/P susceptibility. Methods ： Computerized literature searches of the CNKI, VIP, WanFang, PubMed, Embase and Medline database were conducted to identify all eligible articles. Study subjects were non - syndromic cleft lip with or without cleft palate patients. The pooled odds ratios with 95% confidence interval （CI） were calculated by fixed - effects model or random - effects model. STATA10. 0 was used to do all analysis. Results： This meta- analysis included 1177 cases and 1293 controls from 11 published case- control studies. Taking allele C1 and genotype C1C1 as reference, the C1 C2 or C2 C2 genotype carriers had significantly higher risk of NSCL/P, OR = 2.00 （95%CI, 1.63- 2. 46）. No significant evidence of publication bias was present. Conclusion： This metaanalysis suggests that transforming growth factor αTaq I polymorphism is associated with NSCL/P susceptibility in Chinese population, which C1C2 or C2C2 genotype carries an approximately two - fold increased risk of NSCL/P.

关 键 词：转化生长因子Α 基因多态性 非综合征性唇腭裂 META分析 

分 类 号：R782.21[医药卫生—口腔医学]