凋亡通路Fas/Fasl遗传变异与胃癌发病风险的关系  

Genetic polymorphismsin FAS/FASL System and their association with the risk of gastric cancer

作　　者：刘静[1] 李曙晶[2] 史卫俊[3] 成晓龙[3] 

机构地区：[1]山西医科大学第一医院普外科,太原030001 [2]山西医科大学儿科医学系 [3]山西医科大学解剖学教研室

出　　处：《中国优生与遗传杂志》2012年第8期28-30,共3页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金项目81071625

摘　　要：目的凋亡通路Fas/Fasl在肿瘤的发生发展中起着重要作用,本文探讨Fas/Fasl遗传变异与胃癌易感性的关系。方法以聚合酶链反应-限制性片段长度多态性对218例胃癌患者和218例正常对照进行基因分型,以logistic回归的比值比(OR)及其置信区间(CI)来评估风险度。结果携带Fasl-844TC或CC基因型个体患胃瘤的发病风险均无显著性差异(OR=0.82,95%CI=0.38-1.79;OR=1.84,95%CI=0.86-3.95)。而携带Fas-1377AA基因型的个体胃癌发病风险显著增加,OR为2.13(95%CI=1.15-3.94)。联合作用与交互作用分析发现既携带Fas-1377AA又携带Fasl-844CC基因型的个体发生胃癌的OR增加到4.43(95%CI=1.85-10.62),且Fas-1377G/A多态与Fasl-844T/C多态存在显著相乘交互作用(P=2.02×10-5)。结论 Fas–1377G/A遗传变异可增加胃癌发病风险,Fas–1377G/A与Fasl-844T/C联合与相乘交互作用共同增加胃癌发病风险。Objective ： The Fas and Fasl system plays a substantial role in the development of gastric cancer. This study aimed to evaluate the relationship between genetic variants in FAS/FASL System and the susceptibility to gastric cancer （GC）. Methods： Polymerase chain reaction - based restriction fragment length polymorphism （PCR - RFLP） method was performed to genotype the two SNPs, Fas - 1377G/A and Fasl - 844T/C in 218 GC patients and 218 controls. Odds ratios （ORs） and 95% confidence intervals （CIs） were calculated by logistic regression model. Results： The genotype Fasl -844TC or CC did not show significant association with gastric cancer risk, and the ORs were equal to 0. 82 （95% CI = 0. 38 -1.79） and 1.84 （95% CI = 0. 86 -3.95） , respectively. For Fas -1377 G/A polymorphism, the -1377AA was significant associated with gastric cancer risk, with OR equals 2. 13 （95% CI = 1.15 -3.94）. Combination and multiple interaction analysis showed that an increasing risk of gastric cancer was observed in the individuals carrying Fas - 1377AA and Fasl - 844CC genotypes （ OR = 4. 43, 95% CI = 1.10 - 2. 01 ） and significantly multiplicative interaction were observed between Fas - 1377G/A polymorphism and Fasl -844T/C polymorphism, with Pinteraction, = 2.02 × 10-5）. Conclusion： Our results suggested that the Fas - 1377G/A polymorphisms were associated with increased risk of gastric cancer and the combination and multiple interaction between Fas - 1377G/A and Fasl - 844T/C may contribute to the increased risk of astric cancer.

关 键 词：Fas FASL 基因多态 胃癌 发病风险 

分 类 号：R735.2[医药卫生—肿瘤]