β-珠蛋白生成障碍性贫血患者的内皮粘附分子含量分析  

Levels of endothelial adhesion molecules in patients with β-thalassemia

作　　者：陈群蓉[1] 孙顺昌[2] 彭运生[2] 王清[2] 刘倩如[2] 

机构地区：[1]深圳市宝安区人民医院输血科,518101 [2]深圳市宝安区人民医院检验科,518101

出　　处：《中国优生与遗传杂志》2012年第8期33-34,36,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的对β-珠蛋白生成障碍性贫血患者的血清内皮粘附分子进行分析,探讨β-珠蛋白生成障碍性贫血的血管内皮损伤程度。方法通过酶联免疫吸附法分析130例β-珠蛋白生成障碍性贫血患者的血清血管细胞粘附分子1、细胞间粘附分子1、P-选择素及E-选择素浓度,并与健康对照组进行比较。结果β-珠蛋白生成障碍性贫血患者的血清血管细胞粘附分子1、细胞间粘附分子1、P-选择素及E-选择素浓度分别为(1009.1±409.3)μg/L、(566.4±240.8)μg/L、(93.1±30.6)μg/L、(63.7±28.5)μg/L,显著高于健康对照组的(508.2±239.5)μg/L、(235.5±73.6)μg/L、(57.9±10.1)μg/L、(42.5±10.7)μg/L(P<0.01)。结论β-珠蛋白生成障碍性贫血患者的血管内皮细胞在一定程度被活化,进而导致患者血管内皮损伤。Objective： To analyze serum levels of endothelial vascular endothelial injury for β - thalassemia patients. Methods ： adhesion molecules in patients with β -thalassemia, and explore Serum levels of vascular cell adhesion molecule 1, inter - cellular adhesion molecule 1, P - seleetin, and E - selectin were measured using enzyme - linked immunosorbent assays for 130 patients with 13 -thalassemia and 110 healthy controls. The statistical procedures were performed using grouped t test. Results： Serum levels of vascular cell adhesion molecule 1, inter - cellular adhesion molecule 1, P - selectin, and E - selectin were （ 1009. 1 ±409. 3 ） lag/L, （566.4 ± 240. 8） μg/L, （93.1 ±30. 6） μg/L, （63.7 ± 28. 5） μg/L for patients with β - thalassemia, and （ 508. 2 ± 239. 5 ） μg/ L, （235.5 ±73.6） μg/L, （57. 9 ± 10. 1） μg/L, （42. 5 ± 10. 7） μg/L for healthy subjects, respectively. There were significant differences between β-thalassemia patients and healthy subjects （P 〈 0.01 ）. Conclusion： Endothelial activation and dysfunction are reflected by the increased serum levels of soluble endothelial adhesion molecules in patients with β- thalassemia.

关 键 词：Β-珠蛋白生成障碍性贫血 粘附分子 浓度 

分 类 号：R556.61[医药卫生—血液循环系统疾病]