囊性纤维化跨膜电导调节子基因IVS8-5T与前列腺癌低风险的相关性研究  

Low expression of cystic fibrosis transmembrane conductance regulator gene allele IVS8-5T may be associated with decreased prostate cancer risk

作　　者：乔迪[1] 华立新[2] 易龙[3] 倪黎刚[1] 丁毅[1] 张世革[1] 吴烨[1] 王久林[1] 吴宏飞[2] 

机构地区：[1]江苏省老年医学研究所泌尿外科,南京210024 [2]南京医科大学第一附属医院泌尿外科 [3]南京大学医学院DNA指纹研究室

出　　处：《肿瘤研究与临床》2012年第8期515-517,523,共4页Cancer Research and Clinic

摘　　要：目的探讨囊性纤维化跨膜电导调节子（CFTR）基因功能多态性IVS8-poly（T）与前列腺癌（PCa）风险的相关性。方法通过基于中国汉族人群的病例-对照研究，采用聚合酶链反应-短片段重复序列多态性（PCR-STRP）方法，对230例PCa患者和230名健康对照者的CFTR基因功能多态性位点IVS8-poly（T）进行基因分型，分析等位基因和基因型是否与PCa相关。结果病例组和对照组IVS8-5T等位基因频率分别为1．52％（7／460）和5．22％（24／460），差异有统计学意义（χ^2=12．489、P=0．002）；Logistic回归分析显示5T／7T基因型携带者的PCa患病风险降低（OR=0．232，P=0．003，95％C10．090～0．599）。结论CFFR基因低表达型等位基因IVS8—5T与中国汉族男性PCa低风险有关，可能是PCa的一个保护性因素。Objective To investigate the association between functional polymorphism IVS8-poly （T） in cystic fibrosis transmembrane conductance regulator （CFTR） gene and prostate cancer risk. Methods A population-based case-control study was conducted including 230 prostate cancer patients and 230 agematched controls. PCR-STRP was used to analysis the IVS8-poly （T） tract in CFTR gene. Results The prevalences of the low expression allele, the IVS8-5T, in prostate cancer patients and controls were 1.52 % （7/460） and 5.22 % （24/460）, respectively （χ2 =12.489, P =0.002）. Logistic regression analysis confirmed the 5T/7T genotype was in protective association with prostate cancer risk （OR = 0.232, P = 0.003, 95 % CI 0.090-0.599）. Conclusion The low expression CFTR IVS8-5T allele contributes to a reduced risk of prostate cancer in Chinese Han population, and may be a protective factor against prostate cancer.

关 键 词：前列腺肿瘤 囊性纤维化跨膜电导调节子 基因多态性 

分 类 号：R737.25[医药卫生—肿瘤]