结直肠癌患者血清同型半胱氨酸水平分析  

Analysis of serum homocysteine levels in patients with colorectal cancer

作　　者：张英兰[1] 石红梅[1] 范凝芳[1] 冯宇娇[1] 康艳[1] 

机构地区：[1]山西省肿瘤医院检验科,太原030013

出　　处：《肿瘤研究与临床》2012年第8期550-552,共3页Cancer Research and Clinic

摘　　要：目的探讨结直肠癌患者治疗前后血清同型半胱氨酸（Hcy）水平的变化，为临床疗效观察及预后评估提供依据。方法采用循环酶法测定50例对照组和58例结直肠癌患者治疗前后血清Hcy水平，并随访12个月，观察其变化，分析其与疗效及预后的关系。结果结直肠癌组Hcy水平明显高于对照组[（16．90±5．35）μmol／L比（10．23±3．06）μmol／U（P〈0．01）；并与TNM分期相关，Ⅲ-Ⅳ期患者Hcy水平明显高于Ⅰ～Ⅱ期[（18．49±5．13）Ⅰmol／L比（15．20±4．86）μmol／L]（P〈0．05）。治疗结束时Hcy水平与治疗前相比显著下降[（13．39±4．98）μmol／L比（16．90±5．35）μmol／L]（P〈0．01），且治疗后3个月Hcy水平【（10．23±3．17）μmol／L]明显低于治疗结束时（P〈0．05）。手术后12个月内复发组血清Hcy水平明显高于未复发组【（17．18±4．82）μmol／L比（12．36±3．19）μmol／L】（P〈0．01）。结论血清Hcy水平对结直肠癌疗效观察及预后判断有一定参考价值。Objective To investigate the changes of serum homocysteine （Hcy） level before and after treatment in patients with coloreetal cancer, and provide the reference for clinical therapeutic efficacy and prognosis. Methods Enzymatic circling assay was used to measure the serum Hey levels in 50 controls and 58 patients with coloreetal cancer before and after treatment with a follow-up of 12 months. The changes of Hcy and the relationship between Hcy and therapeutic efficacy or prognosis were analyzed. Results Serum Hcy level in patients with eolorectal cancer was significantly higher than that in controls [（16.90±5.35） μmol/L vs （10.23±3.06） μmol/L] （P 〈 0.01）, and it was closely associated with TNM stage. Serum Hey level in patients of stage Ⅲ-Ⅳ was significantly higher than that of stage Ⅰ - Ⅱ [（18.49±5.13） μmol/L vs （15.20±4.86） μmol/L] （P 〈 0.05）. The Hey level in patients at the end of treatment was significantly lower than that before treatment [（13.39±4.98） μmol/L vs （16.90±5.35） μmol/L] （P 〈 0.01）, and the Hey level after the treatment for 3 month was significantly lower than that at the end of treatment [（10.23±3.17） μmol/L], （P 〈 0.05）. The Hcy level in patients with recurrence during 12 months after operation was significantly higher than that without recurrence [（17.18±4.82） μmol/L vs （12.36±3.19） μmol/L] （P 〈 0.01）. Conclusion Serum level of Hcy might be a useful marker for predicting therapeutic efficacy and prognosis in patients with colorectal cancer.

关 键 词：结直肠肿瘤 同型半胱氨酸 循环酶法 

分 类 号：R735.3[医药卫生—肿瘤]