肾功能不全患者血清胃泌素释放肽前体水平升高  

Elevated serum progastrin-releasing peptide level in patients with renal dysfunction

作　　者：赵敏利[1] 孙桂荣[1] 王盼[1] 初开秋[1] 

机构地区：[1]青岛大学医学院附属医院检验科,山东青岛266003

出　　处：《临床检验杂志》2012年第8期580-582,共3页Chinese Journal of Clinical Laboratory Science

摘　　要：目的观察肾功能不全对血清胃泌素释放肽前体(ProGRP)水平的影响。方法用化学发光法检测120例肾功能不全患者、40例肾功能正常患者、40例小细胞肺癌(SCLC)患者和56例体检健康者的血清ProGRP水平,用脲酶法和苦味酸法分别测定血清尿素(Urea)和肌酐(Cr)水平,并计算内生肌酐清除率(CCr)。结果肾功能不全患者组血清ProGRP水平高于肾功能正常患者组、健康人对照组(P<0.01),但低于SCLC组(P<0.01)。肾功能不全患者代偿期、失代偿期和衰竭期血清ProGRP水平差异有统计学意义(P<0.01)。肾功能不全患者血清ProGRP水平(Y,pg/mL)与血清Urea(X,mmol/L)呈正相关(Y=4.039X+14.220,r=0.629),与Cr水平(X,μmol/L)呈正相关(Y=0.134X+22.394,r=0.795)。结论肾功能不全患者血清ProGRP水平升高,用ProGRP辅助诊断SCLC时应排除肾功能不全。Objective To investigate the effect of renal dysfunction on serum progastrin-releasing peptide （ProGRP） level. Methods The levels of serum ProGRP, urea（Urea） and creatinine （Cr） from 120 patients with renal dysfunction, 40 patients with normal renal function, 40 patients with small cell lung cancer （SCLC） and 56 healthy controls were determined by chemoluminescence method, urease method and picrie acid method, respectively. The endogenous creatinine clearance （Ccr） was calculated. Results The levels of serum ProGRP in the patients with renal dysfunction were significantly higher than those in the patients with normal renal function and the healthy controls （ P 〈 0.01 ）, but significantly lower than those in the patients with SCLC （ P 〈 0.01 ）. There was significant difference of serum ProGRP levels among compensatory stage, decompensatory stage and renal failure stage of the patients with renal dysfunction （P 〈0.01 ）. There was positive correlations between serum ProGRP levels （Y axis, pg/mL） and BUN levels （X axis, mmol/L） （ Y = 4. 039X ＋ 14. 220, n = 120, r = 0. 629 ） , and between serum ProGRP levels （ Y axis, pg/mL） and Cr levels （ X axis, μmol/L） （ Y = 0. 134X ＋ 22. 394, n = 120, r = 0. 795 ）. Conclusion There was increased serum ProGRP level in the patient with renal dysfunction. Therefore, when serum ProGRP level was used as tumor marker of SCLC, the renal dysfunction should be excluded.

关 键 词：肾功能不全 小细胞肺癌 胃泌素释放肽前体 尿素 肌酐 

分 类 号：R734.2[医药卫生—肿瘤]