表皮生长因子在角膜损伤疾病中的应用  

Application of epidermal growth factor in corneal injury

作　　者：梁小华(综述)[1] 梁宗宝(审校)[2] 

机构地区：[1]解放军第一八零医院普外科,泉州362300 [2]解放军第一八零医院眼科,泉州362300

出　　处：《中华实验眼科杂志》2012年第9期857-860,共4页Chinese Journal Of Experimental Ophthalmology

摘　　要：表皮生长因子（EGF）是一种非常重要的多肽类生长因子，不仅参与眼部多种细胞的有丝分裂、增生和分化，而且还具有介导细胞与细胞、细胞与基质之间相互作用及信号转导等生物学功能。角膜损伤是眼科的一种常见病和多发病，如果治疗不恰当，将导致患者失明。许多研究发现，EGF可以促进损伤角膜的修复和再生，近年来该领域的研究已从动物实验阶段进入了临床研究阶段、从形态学研究阶段进入了基因学研究阶段。就EGF的基本概念、生物学效应、与角膜损伤的关系及其在眼科临床的应用等方面的研究进展进行综述，以便更好地指导临床用药。Epidermal growth factor （EGF） is a very important peptide growth factor, which is not only involving in a variety of ocular cell mitosis, proliferation and differentiation, but also participates in mediating the signal transduction between cell and cell,cell and matrix interaction and other biological functions. Corneal injury is a common and frequently occurring disease in ophthalmology, and it would lead to blindness without appropriate treatment. Researches showed that EGF can promote the repair and regeneration of wounded cornea. In recent years, these studies advance from animal experiment stage to clinical stage and also from the morphology evaluation stage to the genetics study stage. This paper provided an overview of EGF concept,its biological effectiveness,its relationship to corneal injury and its clinical application.

关 键 词：表皮生长因子 角膜损伤 角膜上皮细胞 角膜内皮细胞 

分 类 号：R735.2[医药卫生—肿瘤]