大蒜素在重离子放射治疗中的潜在用途  

Potential Application of Garlic on Heavy Ion Radiotherapy

作　　者：许帅[1,2,3,4] 张红[1,2,3] 刘阳[1,2,3] 

机构地区：[1]中国科学院近代物理研究所,甘肃兰州730000 [2]中国科学院重离子束辐射生物医学重点实验室,甘肃兰州730000 [3]甘肃省重离子束辐射医学应用基础重点实验室,甘肃兰州730000 [4]中国科学院研究生院,北京100049

出　　处：《原子核物理评论》2012年第3期294-299,共6页Nuclear Physics Review

基　　金：国家重点基础研究发展计划(973计划)(2010CB834202);国家自然科学基金资助项目(10835011;10675151);甘肃省重大科技专项项目(0702NKDA045;0806RJYA020);中国科学院西部之光人才培养计划项目(XB106012)~~

摘　　要：综述了大蒜素对正常细胞的保护机制和对肿瘤细胞的抑制机制,并将其与辐射保护剂和辐射增敏剂的作用机制进行了比较,提出大蒜素在放射治疗中对正常细胞具有辐射保护效应,而对肿瘤细胞具有辐射增敏效应。设想大蒜素的辐射保护和辐射增敏这种双重效应及其他优点在肿瘤放射治疗中能提高辐射生物学效应,进一步改善治疗效果,在临床应用中具有潜在的价值。Garlic has beneficial effects to protect against many diseases. It can not only protect normal cells from lesion, but also prevent tumorigenesis, proliferation, adhesion, invasion and metastasis. In this pa- per, the mechanisms of these functions of garlic were summarized and compared with radioprotector and radiosensitizer. We presented that garlic has both radioprotective effect on normal cells and radiosensitive effect on tumor cells. By right of its superiority, garlic can improve biological effect in the therapy of heavy ion. Therefore, it has potential value in clinical practice. That is worth for us to explore whether garlic has radioprotective and radiosensitive effect or not.

关 键 词：辐射 辐射保护剂 辐射增敏剂 大蒜素 

分 类 号：R818[医药卫生—放射医学]