DNA含量及细胞核形态参数测定在甲状腺肿瘤中的应用价值  

The applied value of DNA content index and mitotic figure count in thyroid carcinoma

作　　者：方凤琴[1] 李树春[1] 姜力[1] 李奕[2] 邹俊芝[2] 

机构地区：[1]沈阳辽宁省肿瘤医院头颈外科,110042 [2]辽宁省肿瘤医院病理科

出　　处：《耳鼻咽喉（头颈外科）》2000年第2期91-94,共4页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：本文应用图像分析技术 ,对我院 1 996～ 1 998年住院手术治疗的 68例甲状腺癌 ( thyroidcarcinoma,TC)、2 0例甲状腺腺瘤 ( adenoma,AD)、6例腺瘤伴乳头状增生 ( adenoma and popillary,APP)进行了 DNA含量及细胞核形态参数检测。结果显示 :DNA指数、DNA倍体及细胞核形态参数三种检测 ,TC与 AD组对比有显著性差异 ( P <0 .0 1 ) ,TC组与 APP组对比也有明显差异 ( P <0 .0 5)。它提示用针吸病理检查同时追加上述三种检测 ,将是术前鉴别诊断的参数之一。探讨了这三种检测结果与甲状腺癌预后因素的关系及潜在的应用价值。Objective:To evaluate DNA content index and mitotic figure count of thyroid carcinoma.Method:Sixty eight cases of thyroid carcinoma,twenty cases of thyroid adenoma and six cases of thyroid adenoma with papillary proliferation,which were all treated by surgery,were measured by the figure analytic method.Result:In DNA content index,DNA ploidy and mitotic figure count,there were marked difference between thyroid carcinoma and thyroid adenoma (P<0 01) and statistical significance between thyroid carcinoma and papillary proliferation.Conclusion:The needle pathology with the 3 above measuring methods were useful for the preoperative diagnosis of thyroid neoplasm.The 3 methods had certain value in prognosis of thyroid carcinoma. [Chinese Arch Otolaryngol Head Neck Surg,2000;7(2):91~94 From the Department of Head and Neck Surgery,Liaoning Province Cancer Hospital,Shenyang 110042 (Dr.Fang Fengqin)]

关 键 词：甲状腺肿瘤 癌 脱氧核糖核酸 

分 类 号：R736.1[医药卫生—肿瘤]