降糖中药对α-葡萄糖苷酶抑制作用的研究  

Study on Inhibition of the Hypoglycemic Chinese Herbal Medicines on α-glucosidase

作　　者：沈忠明[1] 李英[1] 姜宏 殷建伟[1] 许兆龙[1] 

机构地区：[1]上海大学生命科学学院,201800

出　　处：《中国生化药物杂志》2000年第2期69-70,共2页Chinese Journal of Biochemical Pharmaceutics

基　　金：上海市教委资助

摘　　要：目的：探讨降糖中药对α-葡萄糖苷酶活力的影响。方法：中药水提液通过浸泡、离心、脱色等方法制备；酶活性用PNPG法测定。结果：五味子、虎杖对α-葡萄糖苷酶有强烈的抑制作用。结论：五味子、虎杖可能具有拜糖平样的降糖作用。Purpose: To study the effects of ten herb extracts on α-1, 4-glucosidase activity by establishing an enzyme-inhibitor model. Methods: Glycosidase activity was assayed at pH optima by using the PNPG substrate, The herb extracts were prepared by soaking, centrifugation and decoloration. Results: Wuweizi and Huzhang can strongly inhibit α-1, 4-glucosidase. Conclusion:This finding suggested that their hypoglycemic mechanism was similar to Acarbose.

关 键 词：Α-葡萄糖苷酶 降糖 抑制作用 中药 

分 类 号：R286.715[医药卫生—中药学]