大肠癌组织c-Met和VEGF表达及其与微血管密度关系的初步研究  

Relation of c-Met,VEGF expression and microvessel density in human colorectal carcinoma

作　　者：刘文静[1] 马杰[2] 李克[1] 刘莺[1] 侯新芳[1] 王居峰[1] 

机构地区：[1]河南省肿瘤医院内科,河南郑州450008 [2]河南省肿瘤医院病理科,河南郑州450008

出　　处：《中华肿瘤防治杂志》2012年第15期1159-1161,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨大肠癌组织c-Met和血管内皮生长因子(VEGF)的表达以及两者与肿瘤血管生成的关系及其临床病理学意义。方法:选取经病理确诊的51例大肠腺癌手术切除组织标本,免疫组化SP法检测c-Met和VEGF的表达及微血管密度(MVD)。结果:大肠癌组织中c-Met和VEGF的阳性表达率分别为72.55%(37/51)和52.94%(27/51);与Dukes分期密切相关,P<0.05。大肠癌组织c-Met、VEGF均为阳性时MVD值为37.94±7.53,单一阳性时分别为30.67±1.45和23.82±7.45,均为阴性时MVD值最小,为13.64±5.33。大肠癌组织中c-Met和VEGF的表达呈显著正相关,rs=0.614,P<0.05。结论:c-Met和VEGF在大肠癌发生、发展和转移过程中起重要作用,并与肿瘤血管生成相关。OBJECTIVE： To investigate the expression of c-Met,VEGF in coloreetal carcinoma and their relationship with angiogenesis and the significance of clinicopathology. METHODS： Immunohistochemical SP method was used to de- tect the expression of c-Met and VEGF and microvessel density （MVD） in 51 cases of colorectal carcinoma. RESULTS： The positive expressions of c-Met and VEGF were 72.55% （37/51）, 52.94% （27/51）,which correlated with Dukes stage （P〈0.05）. In colorectal carcinoma,the MVD was 37. 94±7.53 when both c-Met and VEGF was positive expression. When both of them were negative expression, the MVD was 13. 64±5. 33. Cases with single expression were 30. 67 ± 1.45 and 23. 82±7.45, respectively. There was a significant correlationship between the expression of c-Met and VEGF （rs = 0. 614, P〈0.05） in colorectal carcinoma. CONCLUSION： c-Met and VEGF play a key role in the development,inva- sion and metastasis of colorectal carcinoma and correlate with the tumor angiogenesis.

关 键 词：肠肿瘤 受体蛋白质酪氨酸激酶类 血管内皮生长因子 

分 类 号：R735.34[医药卫生—肿瘤]