53例肝细胞癌患者根治性切除术后辅助肝动脉化疗栓塞的生存分析  

Survival Analysis of 53 Patients with Hepatocellular Carcinoma Undergoing Adjuvant Transcatheter Arterial Chemoembolization after Radical Resection

作　　者：漫彦文[1] 刘剑勇[1] 赵荫农[1] 张志明[1] 袁卫平[1] 向邦德[1] 吴飞翔[1] 

机构地区：[1]广西医科大学附属肿瘤医院肝胆外科,南宁市530021

出　　处：《中国肿瘤临床》2012年第17期1321-1324,共4页Chinese Journal of Clinical Oncology

基　　金：广西医疗卫生重点科研课题(编号:重200611);广西科学研究与技术开发计划项目(编号:桂科攻0719006-2-5);广西科学基金项目(编号:桂科自0728196)资助~~

摘　　要：目的:探讨肝细胞癌根治性切除术后辅助肝动脉化疗栓塞对无瘤生存率及累积生存率的影响方法:收集53例肝细胞癌根治性切除术后辅助TACE治疗患者和64例单纯行肝细胞癌根治术后患者的临床资料,采用回顾性研究的方法,对其治疗的1、2、3、5无瘤生存率和累积生存率进行对比分析,从而探讨肝细胞癌根治性切除术后辅助TACE治疗对无瘤生存率及累积生存率的影响结果:术后+TACE组1、2、3、5年的无瘤生存率和累积生存率分别为84.9%、60.4%、39.6%、1 8.9%和98.1%、86.8%、69.8%、47.2%,单纯手术组1、2、3、5年的无瘤生存率和累积生存率分别为70.3%、43.8%、21.9%、12.5%和87.5%、71.9%、50.0%、31.3%,两组的无瘤生存率和累积生存率差异均有统计学意义Cox回归结果显示术后+TACE治疗是影响患者无瘤生存率和累积生存率的独立影响因素结论:肝细胞癌根治性切除术后辅助TACE治疗可提高患者的无瘤生存率和累积生存率。Objective： This study investigates the effect of adjuvant trans-catheter arterial chemo-embolization （TACE） treatment after radical resectioning of the hepato-cellular carcinoma （HCC） on disease-free and accumulative survivals. Methods： The clinical data of 53 HCC patients who underwent postoperative adjuvant TACE treatment and 64 patients undergoing simple surgery of HCC were collected. The 1-, 2-, 3-, and 5-year disease-free and accumulative survival rates of the patients were retrospectively studied to analyze the effect of auxiliary TACE treatment on disease-free and accumulative survival rates after HCC surgery. Results： The 1-, 2-, 3-, and 5-year disease-free and accumulative survival rates in the group with TACE treatment after resection were 84.9%, 60.4%, 39.6%, and 18.9%, and 98.1%, 86.8%, 69.8%, and 47.2% respectively. The disease-free and accumulative survival rates of the group with simple HCC surgery were 70.3%, 43.8%, 21.9%, and 12.5%, and 87.5%, 71.9%, 50.0%, and 31.3%, respectively. The log-rank test for the two groups were statistically different between the two cases. The COX regression equation results showed that the treatment with radical surgery plus adjuvant TACE is an independent factor that affects the disease-free and accumulate survival rates. Conclusion： TACE treatment after HCC radical surgery is an independent factor that can improve the disease-free and accumulative survival rates of the patients.

关 键 词：肝细胞癌 根治性切除术 肝动脉化疗栓塞 生存分析 

分 类 号：R735.7[医药卫生—肿瘤]