5-hydroxymethyl-2-furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain ischemia  

作　　者：Bailiu Ya Lan Zhang Li Zhang Yali Li Lin Li 

机构地区：[1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China [2]Department of Physiology, Jining Medical University, Jining 272067, Shandong Province, China

出　　处：《Neural Regeneration Research》2012年第22期1722-1728,共7页中国神经再生研究（英文版）

基　　金：supported by the National Basic Research Program of China (973 Program),No.2003CB517104;the National Natural Science Foundation of China,No.30973513;Beijing Municipal Science and Technology Program,No.D0206001043191;the Natural Science Foundation of Beijing,No.7112061;Beijing Key Foundation of Traditional Chinese Medicine,No.KJTS2011-04;Beijing Health and Technical Personal of High-Level Plan,No.2009-3-66

摘　　要：In the present study, we hypothesized that 5-hydroxymethyl-2-furfural could attenuate ischemic brain damage by reducing oxidative injury. Thus, mice were subjected to bilateral common carotid artery occlusion to establish a model of permanent forebrain ischemia. The mice were intraperitoneally injected with 5-hydroxymethyl-2-furfura130 minutes before ischemia or 5 minutes after ischemia. The survival time of mice injected with 5-hydroxymethyl-2-furfural was longer compared with untreated mice. The mice subjected to ischemia for 30 minutes and reperfusion for 5 minutes were intraperitoneally injected with 5-hydroxymethyl-2-furfural 5 minutes prior to reperfusion, which increased superoxide dismutase content and reduced malondialdehyde content, similar to the effects of Edaravone, a hydroxyl radical scavenger used for the treatment of stroke. These findings indicate that intraperitoneal injection of 5-hydroxymethyl-2-furfural can prolong the survival of mice with permanent forebrain ischemia. This outcome may be mediated by its antioxidative effects.In the present study, we hypothesized that 5-hydroxymethyl-2-furfural could attenuate ischemic brain damage by reducing oxidative injury. Thus, mice were subjected to bilateral common carotid artery occlusion to establish a model of permanent forebrain ischemia. The mice were intraperitoneally injected with 5-hydroxymethyl-2-furfura130 minutes before ischemia or 5 minutes after ischemia. The survival time of mice injected with 5-hydroxymethyl-2-furfural was longer compared with untreated mice. The mice subjected to ischemia for 30 minutes and reperfusion for 5 minutes were intraperitoneally injected with 5-hydroxymethyl-2-furfural 5 minutes prior to reperfusion, which increased superoxide dismutase content and reduced malondialdehyde content, similar to the effects of Edaravone, a hydroxyl radical scavenger used for the treatment of stroke. These findings indicate that intraperitoneal injection of 5-hydroxymethyl-2-furfural can prolong the survival of mice with permanent forebrain ischemia. This outcome may be mediated by its antioxidative effects.

关 键 词：5-hydroxymethyl-2-furfural forebrain ischemia survival time oxidative stress SUPEROXIDEDISMUTASE MALONDIALDEHYDE MOUSE 

分 类 号：Q582[生物学—生物化学] TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]