miR-19与肿瘤  

MicroRNA-19 and neoplasms

作　　者：孙即奎[1] 贾志凡[1] 杨卫东[1] 

机构地区：[1]天津医科大学总医院神经病学研究所神经肿瘤室 天津医科大学总医院神经外科,300052

出　　处：《国际肿瘤学杂志》2012年第9期643-646,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目（30872985）;天津市应用基础研究计划面上项目（06YFJMJC07900）

摘　　要：miR-17～92基因簇编码6种成熟的miRNA，包括miR-17、miR-20a、miR-18a、miR-19a、miR-19b和miR-92a—1，是-类典型的致癌多作用子miRNA。miR-19（包括miR．19a和miR-19b）是其中最重要的致癌miRNA，在淋巴瘤、白血病、肺癌、乳腺癌、多发性骨髓瘤等肿瘤中均表达上调，成为研究的热点之-。miR-19可通过抑制靶基因如PTEN、PP2A、Bim、SOCS1等促进肿瘤的增殖、侵袭和转移，与P13K—AKT-mTOR信号转导通路关系密切，在肿瘤的发生发展中起着非常重要的作用。The miR-17-92 cluster, consisting of six individual, mieroRNAs, including miR-17, miR-20a, miR-18a, miR-19a, miR-19b and miR-92a-I, is a kind of typical oncogenic polycistron microRNA. MiR-19 （containing miR-19a and miR-19b） , as the key oncogenic component in miR-17-92 cluster, is overex- pressed in human cancers including lymphomas, leukaemia, lung cancer, breast cancer and multiple myeloma, and has been one of research focus in recent years. It is found that miR-19 promotes tumor growth,invasion and metastasis through negative regulation of target genes such as PTEN, PP2A, Bim, SOCS1, and is correlated strongly with PDK-AKT-mTOR pathway. MiR-19 plays an important role in tumor genesis and development.

关 键 词：miR-19 肿瘤 淋巴瘤 白血病 

分 类 号：R730.2[医药卫生—肿瘤]