原发性肝癌行肝动脉化疗栓塞术围手术期血清甲胎蛋白、癌胚抗原水平的观察与分析  

The observation and analysis of the levels of perioperative serum alpha-fetoprotein and carcinoembryonic antigen in patients with primary liver cancer undertaken transcatheter arterial

作　　者：魏本尊[1] 沈超[1] 孙广涛[1] 亓荣华[1] 

机构地区：[1]滨州医学院附属淄博市中心医院普外科,255036

出　　处：《中国医师进修杂志》2012年第26期32-34,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨原发性肝癌行肝动脉化疗栓塞术（TACE）围手术期血清甲胎蛋白（AFP）、癌胚抗原（CEA）水平变化。方法102例原发性肝癌患者，均行TACE治疗，术后3d、1周、3周观察患者血清AFP、CEA水平的变化。结果血清AFP水平术后3d及术后1周高于术前[（549±30）、（530±30）μg/L比（527±40）μg／L]，但差异无统计学意义（P〉0．05），术后3周AFP水平明显降低[（351±20）μg/L]，与术前比较差异有统计学意义（P〈0．05）；血清CEA水平术后3d、术后1周及术后3周均低于术前（410±15）、（350±20）、（200±10）μg／L比（570±22）μg／L]，差异有统计学意义（P〈0．05），术后3周患者血清AFP、CEA水平均为正常水平。结论对原发性肝癌患者行TACE，可以明显改善患者的症状，降低患者血清AFP、CEA水平，给予患者有效的治疗，掌握TACE的适应证及禁忌证，进而及时正确地给予患者施行TACE，可以降低患者病死率，改善长期预后，值得临床推广应用。Objective To explore the change of perioperative serum alpha-fetoprotein （AFP） and carcinoembryonic antigen （CEA） in patients with primary liver cancer undertaken transcatheter arterial chemoembolization （TACE）. Methods One hundred and two patients with primary liver cancer were performed with TACE treatment. The levels of AFP and CEA after treatment 3 d, 1 week, 3 weeks were detected and compared. Results The levels of AFP after treatment 3 d and 1 week were higher than that before treatment, but there was no significant difference [ （549 ± 30）, （530 ± 30）μ g/L vs. （527 ± 40） μg/L] （P 〉0.05）. After treatment 3 weeks, the levels of AFP significantly decreased than that before treatment [ （351 ± 20） μg/L vs. （527 ± 40）μ g/L ] （P 〈 0.05）. The levels of CEA after treatment 3 d, 1 week, 3 weeks were significantly lower than that before treatment [ （410 ± 15）, （350 ± 20）, （200 ± 10） μg/L vs. （570 ± 22） μg/L] （P 〈 0.05）. After treatment 3 weeks, the levels of AFP and CEA achieved normal. Conclusions TACE in treatment for primary liver cancer can achieve better therapeutic effect, significantly improve the symptoms, decrease the levels of AFP and CEA. To control the indication and contraindication, perform TACE in time can decrease mortality, improve prognosis, and is valuable in clinic.

关 键 词：肝肿瘤 栓塞 治疗性 癌胚抗原 甲胎蛋白类 

分 类 号：R735.7[医药卫生—肿瘤]