胃癌患者血清层粘连蛋白及Ⅳ型胶原的检测及意义  

Determination and Significance of Serum Laminin and Type Ⅳ Collagen in Patients with Gastric Cancer

作　　者：陈金国[1] 柴明胜[1] 

机构地区：[1]上海海军医学研究所一室,上海200433

出　　处：《中国医师杂志》2000年第3期149-150,共2页Journal of Chinese Physician

摘　　要：为探讨胃癌患者血清层粘连蛋白 (LN)和Ⅳ型胶原 (Ⅳ -C)变化规律及其意义 ,本文应用放射免疫分析方法测定 2 0例胃癌患者及 15例对照病人血清LN、Ⅳ -C浓度。结果表明胃癌患者血清LN、Ⅳ -C含量均显著高于对照组 ,升高比例为 4 4 4 %和 55 0 %。进展期 (TNMⅡ、Ⅲ、Ⅳ期 )胃癌二者血清含量较早期 (TNMⅠ期 )明显升高 ,有淋巴结转移的较无转移者高。但肿瘤各组织细胞学类型间二者水平均未见统计学差异。结果提示胃癌患者血清LN、Ⅳ -C含量与肿瘤的浸润及转移有密切关系 ,观察血清LN、Ⅳ -C含量及变化 ,对胃癌患者的病情及预后判断有重要参考价值。To investigate the regularity and significance of changes of serum laminin (LN) and type Ⅳ collagen (Ⅳ-C) in patients with gastric cancer,the levels of LN and IV-C in sera from 20 cases of gastric cancer and 15 cases of control were determined with commercial radioimmunoassay kits.The contents of LN and Ⅳ-C in cancer group were elevated by 44.4% and 55.0% respectively,significantly higher than those in control group.And both proteins in cases of progressive stage (TNM stage Ⅱ,Ⅲ,Ⅳ) were statistically higher than those in early stage.Furthermore,they were higher in cases with positive lymph node metastasis,as compared with that of negative cases.But no certain correlation was found between the levels of LN and Ⅳ-C and types of tumor cells.The results suggest that the contents of LN and Ⅳ-C in sera are closely related to tumor invasion and metastasis,and the both could be useful in monitoring the gastric cancer status and its prognosis.

关 键 词：胃肿瘤 层粘连蛋白 Ⅳ型胶原 检测 

分 类 号：R735.2[医药卫生—肿瘤]