DNA切除修复基因XPD在肝癌中遗传易感性的荟萃分析  

Association of the xeroderma pigmentosum group D DNA repair gene with hepatocellular carcinoma

作　　者：张佳骥[1] 马建忠[1] 

机构地区：[1]中国医科大学基础医学部,沈阳110001

出　　处：《中华肝脏病杂志》2012年第9期683-687,共5页Chinese Journal of Hepatology

摘　　要：目的探讨DNA切除修复基因XPD基因多态性在中国人群原发陛肝癌中的遗传易感性。方法检索中外数据库，获得有关XPD基因多态性与肝癌发病风险的病例对照研究资料进行Meta分析，得到合并的优势比（OR）和95％可信区间（95％锄。结果共纳入XPD基因多态位点相关文献6篇，累计病例3424例，对照3636例；在XPD基因多态位点751和312位点等位基因的OR（95％CI）分别为1．25（0．70～2．24）和0．85（0．58～1．25）；在XPD基因多态位点751，与野生基因型Lys／Lys相比，（Lys／Gln＋Gln／Gln）合并的OR（95％CI）为1．31（0．71～2．42）；在XPD基因多态位点312位点，与野生基因型Asp／Asp相比，（Asp／Asn＋Asn／Asn）合并的OR值（95％甜）为1．19（0．73～1．95）。结论XPD多态性遗传位点751和312不是中国人群原发性肝癌发病的风险因素。Objective To explore the association between polymorphisms in the DNA repair gene, xeroderma pigmentosum group D （XPD）, and development of hepatocellular carcinoma （HCC） in the Chinese population by performing a systematic review of the previously published clinical data. Methods A comprehensive literature search of the BIOSIS Previews and PubMed databases was carried out to identify all case-control studies of XPD polymorphisms and HCC risk. Meta-analysis was conducted to calculate the pooled odds ratios （ORs） with 95% confidence intervals （CIs） of developing HCC for carriers of the various XPD polymorphisms. Results Six case-control studies were selected for this meta-analysis, and comprised a total of 3424 HCC cases and 3636 controls. The pooled ORs （95% CIs） of XPD codon 751 and 312 aUelomorphs were 1.25 （0.70 - 2.24） and 0.85 （0.58 - 1.25）, respectively. Compared with the XPD wild-type homozygote Lys/Lys genotype of codon 751, the pooled OR （95% CI） of Lys/Gln ＋ Gin/Gin genotypes for HCC risk was 1.31 （0.71 - 2.42）. Compared with the XPD wild-type homozygote Asp/Asp genotype of codon 312, the pooled OR （95% CI） ofAsp/Asn ＋ Asn/Asn genotypes for HCC risk was 1.19 （0.73 - 1.95）. Conclusion Polymorphisms in the XPD codons 751 and 312 are not associated with HCC risk in the Chinese population.

关 键 词：癌 肝细胞 着色性干皮病基因D组 多态性 基因 META分析 

分 类 号：R735.7[医药卫生—肿瘤]