促血管生成素-2在反复自然流产绒毛膜中的表达  

Expression of angiopoietin-2 in chorion of patients with recurrent spontaneous abortion

作　　者：沈寅琛[1] 甘柏柳[1] 陆洪波[1] 王靖[1] 陈纡[2] 莫发荣[2] 

机构地区：[1]广西南宁市妇幼保健院优生遗传科,530011 [2]广西医科大学组织学与胚胎学教研室

出　　处：《中国妇幼保健》2012年第27期4253-4255,共3页Maternal and Child Health Care of China

基　　金：广西壮族自治区卫生厅科研课题〔Z2009256〕;南宁市科学研究与技术开发计划项目〔201003049C-2〕

摘　　要：目的:探讨反复自然流产(RSA)与促血管生成素-2(Ang-2)的关系。方法:用免疫组化法检测33例反复自然流产患者和37例健康早孕人工流产妇女的绒毛膜组织中Ang-2的表达水平。结果:自然流产组Ang-2的表达高于人工流产组,差异有统计学意义(P<0.05);两组Ang-2的表达均与年龄无关(P>0.05);自然流产组Ang-2的表达与胚胎孕周呈正相关(P<0.05),而人工流产组Ang-2的表达与胚胎孕周无关(P>0.05)。结论:Ang-2的高表达可能是造成自然流产的原因之一。Objective： To explore the relationship between recurrent spontaneous abortion （RSA） and angiopoietin -2. Methods： The expression levels of angiopoietin - 2 in chorionic tissues of 33 patients with RSA and 37 healthy early pregnant women receiving artificial abortion were detected by immunohistochemical method. Results ： The expression level of angiopoietin - 2 in spontaneous abortion group was statistically significantly higher than that in artificial abortion group （ P 〈 0. 05 ） ; the expression levels of angiopoietin - 2 in the two groups were not correlated with age （P 〉 0. 05） ; there was a positive correlation between the expression of angiopoietin - 2 and gestational weeks in spontaneous abortion group （ P 〈 0. 05 ）, while in artificial abortion group, the expression of angiopoietin - 2 was not related to gestational weeks （P 〉 0. 05） . Conclusion： High expression of angiopoietin - 2 may be one of the causes of RSA.

关 键 词：反复自然流产 促血管生成素-2 绒毛膜 

分 类 号：R714.21[医药卫生—妇产科学]