脑卒中患者血浆溶血磷脂酸含量动态变化的临床研究  

Clinical study of dynamic changes of plasma lysophosphatidic acid levels in patients with stroke

作　　者：吴晓燕[1] 

机构地区：[1]山东省菏泽市立医院神经内科,274031

出　　处：《中国实用医刊》2012年第19期11-13,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨脑出血与脑梗死、短暂性脑缺血发作患者血浆溶血磷含量动态变化的特点及临床意义，探究其病理生理机制，为临床防治提供依据。方法选取经临床和辅助检查确诊的脑出血患者130例、脑梗死患者160例、短暂性脑缺血发作患者100例，测定其发病24h和3d、1周、2周、3周时血浆溶血磷脂酸（LAP）的含量。以年龄匹配的健康体检者110例作为对照组。结果发病24h时，血浆LPA浓度排列顺序为：TIA组最高，脑梗死组次之，脑出血组及对照组依次降低；发病3d时，血浆LPA浓度排列顺序为：脑梗死最高，TIA组次之，脑出血组及对照组依次降低；发病1周时，血浆LPA浓度排列顺序为：脑出血组最高，TIA组及脑梗死组次之，对照组依次降低；发病3周时，TIA组、脑梗死组、脑出血组与对照组之间LPA浓度比较，差异无统计学意义。结论脑出血与脑梗死、短暂性脑缺血发作发生脑损伤的病理生理机制不同，三者治疗应采取不同的策略。Objective To investigate the characteristics and clinical meaning of the changes of plasma lysophosphatidic acid （LPA） levels in patients with intracerebral hemorrhage dynamic （ICU）, cerebral infarction （CI） and transient ischemic attack （TIA） and the pathophysiologic mechanism of the disease, in order to provide evidence for the clinical prevention and treatment. Methods One hundred and thirty patients with ICH, 160 patients with CI and 100 patients with TIA were selected in this study. The plasma lysophosphatidic acid （LPA） were detected at 24 h and 3 days, 1 week, 2 weeks, 3 weeks after the onset. One hundred and ten age-matching healthy subjects were choosed as choosed control group. Results Twenty-four hours after the onset, the level of plasma LPA in TIA group was significantly higher than that in ICH group, CI group and control group; At 3 d after the onset, the level of LPA in CI group were the highest; One week after the onset, the level of LPA in ICH group was higher than that in the CI,TIA and control groups. Three weeks after the onset, there was no significant difference in the level of plasma LPA between TIA group, CI group, ICH group and control group. Conclusions The pathophysiologic machenisms of intracerebral hemorrhage, transient ischemic attack and cerebral infarction are different, and different thera- pies should be offered accordingly.

关 键 词：脑出血 脑梗死 溶血磷脂酸 

分 类 号：R74[医药卫生—神经病学与精神病学]