DNMTl - mediated PTEN hypermethylation confers HSCs activation and fibrogenesis in rat liver  

作　　者：Er-Bao Bian Jun Li 

机构地区：[1]Key Laboratory of Natural Product Bioactivity of Anhui Province [2]Three-level Laboratory of Scientific Research of Traditional Chinese Medicineof State Administration of Traditional Chinese Medicine of People' sRepublic of China "Pharmacology of Traditional Chinese Medicine"Hefei. Anhui 230032, China

出　　处：《中国药理通讯》2012年第3期62-62,共1页

摘　　要：Hepatic stellate cell （HSC） activation is an essential event during liver fibrogene- sis. Phosphatase and tension homolog deleted on chromosome 10 （PTEN）, a tumor suppressor, is a negative regulator of this process. PTEN promoter hypermethylation is a major epigenetic si- lencing mechanism in tumors. The present study aimed to investigate whether PTEN promoter methylation was involved in HSCs activation and liver fibrosis, we observed that hypermethyla- tion of PTEN gene was responsible for the decrease of PTEN expression during HSCsHepatic stellate cell （HSC） activation is an essential event during liver fibrogene- sis. Phosphatase and tension homolog deleted on chromosome 10 （PTEN）, a tumor suppressor, is a negative regulator of this process. PTEN promoter hypermethylation is a major epigenetic si- lencing mechanism in tumors. The present study aimed to investigate whether PTEN promoter methylation was involved in HSCs activation and liver fibrosis, we observed that hypermethyla- tion of PTEN gene was responsible for the decrease of PTEN expression during HSCs activation

关 键 词：TTP HSC SOD 药理学 PTEN 

分 类 号：R95[医药卫生—药学]