MicroRNA- 146a modulates TGF- betal-induced hepatic stellate cells proliferation by targeting SMAD4  

作　　者：Yong He Jun Li 

机构地区：[1]UniversityCollege of Pharmacy, Anhui Medical [2]Key Laboratoryof Natrual Product Bioactivity of Anhui Province, Three-level Laboratoryof Scientific Research of Traditional Chinese Medicine of State Administationof Traditional Chinese Medicine of People~ s Republic of China " Pharmacologyof Traditional Chinese Medicine ", Hefei, Anhui 230032, China

出　　处：《中国药理通讯》2012年第3期63-63,共1页

摘　　要：Background/Aims： To reveal the miR-146a expression and related roles in TGF-β1-in- duced hepatic stellate cells activation. Methods. miR-146a expression was analyzed in TGF-β1-treated HSC and CC14-in- duced liver brotic tissues by one--step real--time quantitative PCR. Furthermore, the effects of miR--146a on the TGF--131-- induced HSC proliferation were investigated by MTT assay,Background/Aims： To reveal the miR-146a expression and related roles in TGF-β1-in- duced hepatic stellate cells activation. Methods. miR-146a expression was analyzed in TGF-β1-treated HSC and CC14-in- duced liver brotic tissues by one--step real--time quantitative PCR. Furthermore, the effects of miR--146a on the TGF--131-- induced HSC proliferation were investigated by MTT assay,

关 键 词：TTP HSC SOD 药理学 MicroRNA- 146a 

分 类 号：R95[医药卫生—药学]