急性脑梗死患者血清白介素-6水平与颈动脉斑块的关系探讨  

Relationship between carotid artery plaque and serum interleukin-6 level in patients with acute cerebral infarction

作　　者：常景环[1] 

机构地区：[1]郑州市第一人民医院神经内科,郑州450004

出　　处：《中国实用神经疾病杂志》2012年第17期11-13,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨急性脑梗死患者血清白介素-6(Interleukin-6,IL-6)水平的变化与颈动脉斑块的关系。方法将151例急性脑梗死患者根据颈动脉超声检查分为3个亚组,即无斑块组42例,稳定斑块组53例,不稳定斑块组56例,抽取上述3组患者发病急性期2d和恢复期14d时空腹静脉血,采用双抗体夹心酶联免疫吸附法测定血清IL-6的水平,并与45例健康对照者进行对比。结果 (1)脑梗死急性期2d不稳定斑块组的IL-6水平明显高于稳定斑块组、无斑块组及对照组,稳定斑块组的IL-6水平明显高于无斑块组及对照组,无斑块组的IL-6水平明显高于对照组,差异均具有统计学意义(F=57.46,P<0.05)。(2)脑梗死恢复期14d不稳定斑块组的IL-6水平明显高于稳定斑块、无斑块组及对照组,稳定斑块组的IL-6水平明显高于无斑块组及对照组,差异均有统计学意义(F=46.31,P<0.05),无斑块组与对照组差异无统计学意义(P>0.05)。结论急性脑梗死患者血清IL-6的水平与斑块形成以及斑块的稳定性密切相关。Objective To explore the relationship between carotid artery plaque and serum interleukin-6 level in patients with acute cerebral infarction. Methods Totally 151 patients with acute cerebral infarction were divided into three subgroups by using carotid ultra-sonographic methods, no carotid plaques group （n= 42）, stable plaque group （n= 53）, and vulnerable plaques group （n=56）. Forty-five healthy people were selected as control group. Serum IL-6 was measured by enzyme linked immunosorbent assay （ELISA） in the second day and the fourteenth day. Results In the second day of infarction, the IL-6 lev- el of vulnerable plaques group was significantly higher than that in stable plaque group, no carotid plaques group and control group, IL-6 level of stable plaque group was significantly higher than that in no carotid plaques group and control group, and IL-6 level of no carotid plaques group was significantly higher than that in control group, the differences were statistically significant （F=57.46, P〈0.05）. In the fourteenth day of infarction, IL-6 level of vulnerable plaques group was significantly higher than that in stable plaque group, no carotid plaques group and control group, and IL-6 level of stable plaque group was significantly higher than that in no carotid plaques group and control group, the differences were statistically significant （F= 46.31, P〈0.05）. There was no significant difference between no carotid plaques group and control group（P〈0.05）. Conclusion The level of serum IL-6 in patients with acute cerebral infarction is closely related with plaque formation and plaque stability.

关 键 词：急性脑梗死 IL-6 颈动脉斑块 

分 类 号：R743.33[医药卫生—神经病学与精神病学]