特利加压素比较施他宁治疗急性食管静脉曲张破裂出血  

Terlipressin vs.Stilamin for the treatment of acute bleeding from esophageal varices

作　　者：刘诗[1] 许军英[1] 侯晓华[1] 易粹琼[1] 

机构地区：[1]同济医科大学附属协和医院消化内科,武汉43022

出　　处：《胃肠病学和肝病学杂志》2000年第1期60-62,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的　比较特利加压素和施他宁治疗肝硬化患者急性食管静脉曲张破裂出血的疗效和安全性。方法　特利加压素治疗组 41例 ,静推 2mg后 ,每 4h静推 1mg ;施他宁治疗组 43例 ,静注 2 5 0 μg后 ,每 1h 2 5 0 μg连续静滴。观察两种药物的止血率、再出血率、死亡率和副作用。结果　特利加压素组治疗有效率 ( 80 5 % )类似于施他宁组 ( 83 7% ) ;两组再出血率分别为 19 5 %和 2 3 3 % (P >0 .0 5 ) ,死亡率分别为 12 2 %和 16 3 % (P >0 .0 5 )。特利加压素组副作用发生率为 7 3 % ,施他宁组无明显副作用。Aim To compare the efficacy and safety of terlipressin and stilamin for the treatment of acute variceal bleeding in cirrhotic patients.Method Of 84 patients with acute variceal bleeding,41 were choosen randomly to be given terlipressin (2mg and then 1mg/4hr by intravenous injection). The remaining were given stilamin(250μg by intravenous injection and then continuous infusion of 250 μg/h).Results Success of therapy in terlipressin group(80.5%)was similar to that in stilamin group(83.7%).The rates of repeated bleeding of the two groups were 19.5% and 23.3% respectively(P>0.05).No differences were observed in the mortality rates of the two groups(12.2% vs.16.3%).Side effects occurred in 7.3% of the patients treated with terlipressin;there were no obvious side effects in the stilamin group.Conclusion Terlipressin and stilamin are effective as first-line for the treatment of acute variceal bleeding in cirrhotic patients.

关 键 词：特利加压素 施他宁 食管静脉曲张 出血 治疗 

分 类 号：R571.305[医药卫生—消化系统]