肺癌血管的检测及临床意义  

作　　者：卢敏[1] 高克明[1] 

机构地区：[1]沈阳市中国医科大学附属第一医院局解手术学教研室,110001

出　　处：《中国局解手术学杂志》2000年第2期109-110,共2页

摘　　要：目的 为了更好地评价肺癌的良恶性。方法 采用抗H单抗,以ABC免疫组化方法对119例肺癌间质血管进行免疫病理学研究,以检测肺癌间质血管密度及其与肺癌病理分化程度、淋巴结转移的关系。结果 肿瘤血管密度在各类型肺癌无显著性差异(P>0.05)。Ⅰ期肺癌中血管密度显著低于Ⅱ期和Ⅲ期肺癌(P<0.01),发生淋巴结转移组血管密度高于无淋巴结转移组(P<0.01)。结论 肺癌血管密度可做为评价肺癌恶性程度的指标,并促进淋巴结转移和肺癌的发展。Objective To measure the tumor angiogenesis in primary lung cancer and study the relationship between it and lymph node metastasis. Methods Intratumor microvessel was detected by using ABC immunohistchemistry. Results Tumor microvessel density has no relationship among all types of lung cancer (P > 0.05 ) . microvessel density in stage Ⅰ is significantly lower than those in stage Ⅱ and Ⅲ (P<0.01). Microvessel density is higher in the tumors with lymph node metastasis than not (P < 0.01). Conclusion Tumor angiogenesis play an important role in the growth and metastasis of lung cancer.

关 键 词：肺癌 血管密度 免疫组化 检测 

分 类 号：R734.2[医药卫生—肿瘤]