新辅助化疗对局部晚期子宫颈鳞癌近期疗效的分析  

Evaluation of the Clinical Effects of Neoadjuvant Chemotherapy on Locally Advanced Cervical Squamous Cancer

作　　者：姚霁航[1] 郭科军[1] 

机构地区：[1]中国医科大学附属第一医院妇科,沈阳110001

出　　处：《中国医科大学学报》2012年第9期834-837,共4页Journal of China Medical University

摘　　要：目的比较两种不同术前新辅助化疗方案在局部晚期子宫颈鳞癌治疗中的疗效。方法选取2004年1月至2010年12月我院Ⅰb2~Ⅱa期子宫颈鳞癌患者54例,患者均知情同意,随机分为2组,行术前新辅助化疗,其中42例（PEB组）采取顺铂＋依托泊苷＋博来霉素（PEB）方案,12例（PVB组）采取顺铂＋长春新碱＋博来霉素（PVB）方案,比较2组患者不良反应、临床症状缓解及术后病理的检查结果。结果 PEB组新辅助化疗有效率为85.7%,PVB组为83.3%,2组比较无统计学差异（P〉0.05）;PEB组患者骨髓抑制等化疗不良反应发生率较PVB组降低,但差异无统计学意义（P〉0.05）,术后病理淋巴结阳性率及子宫旁浸润2组比较差异无统计学意义（P〉0.05）。结论 PEB和PVB化疗方案对治疗局部晚期子宫颈鳞癌均有效。Objective To compare clinical effects of the two different neoadjuvant chemotherapies on locally advanced cervical squamous cancer（LACC）.Methods A total of 54 patients with stage Ⅰb2-Ⅱa of cervical squamous cancer admitted in the first hospital affiliated to the China Medical University during 2004-2010 were analyzed retrospectively.Totally 42 patients were treated by preoperative neoadjuvant chemotherapy with PEB（cisplatin,etoposide and bleomycin） regimen,and others received PVB（cisplatin,vincristine and bleomycin） regimen.The side effects of chemotherapy,remission of the clinical symptoms and histology were analyzed.Results The effective rate of PEB and PVB chemotherapy were 85.7% and 83.3%,respectively;there was no significant difference between the two group（s P 〉 0.05）;the side effects of PEB regimen in bone marrow suppression were slighter than PVB regimen,and there was no significant difference between the two groups.There was no significant difference between the two groups in metastatic lymph nodes ratio or para-metrium invasion.Conclusion The neoadjuvant chemotherapy with two regimens were effective treatments of the locally advanced cervical squamous cancer,there was no significant difference between the two groups.

关 键 词：子宫颈癌 新辅助化疗 疗效 

分 类 号：R737.33[医药卫生—肿瘤]