光动力疗法治疗黄斑中心凹下脉络膜新生血管膜的疗效观察  

Therapeutic observation of photodynamic therapy on subfoveal choroidal neovascularization

作　　者：陈放 杨晓燕 陈燕 庄朝荣 解正高 

机构地区：[1]扬州大学临床医学院,江苏扬州225001

出　　处：《实用临床医药杂志》2012年第13期62-64,共3页Journal of Clinical Medicine in Practice

摘　　要：目的观察光动力疗法(PDT)治疗黄斑中心凹下脉络膜新生血管膜(CNV)的疗效和安全性。方法回顾性分析行PDT治疗的黄斑中心凹下CNV患者32例(39眼),其中年龄相关性黄斑变性14例(19眼)、病理性近视12例(14眼)、特发性脉络膜新生血管6例(6眼)。对比分析PDT治疗前后患者最佳矫正视力(BCVA)、眼底荧光血管造影(FFA)、光学相干断层扫描(OCT)检查结果。PDT治疗后平均随访时间15个月。结果 PDT治疗后末次随访时,视力提高10眼(25.64%),视力稳定不变者23眼(58.97%),视力下降6眼(15.38%)。FFA与OCT检查显示:CNV完全闭合者17眼(43.59%),CNV部分闭合者9眼(23.07%),CNV小部分闭合者8眼(20.51%),CNV复发者5眼(12.82%)。结论 PDT治疗黄斑中心凹下CNV是安全有效的。Objective To investigate the efficacy and safety of photodynamic therapy（PDT） on subfoveal choroidal neovascularization.Methods The clinical data of 32 patients（39 eyes） with subfoveal CNV treated with verteporfin PDT were retrospectively analyzed.All patients received verteporfin PDT and were followed clinically with best corrected visual acuity（BCVA）,fundus fluorescein angiography（FFA） and optic coherence tomograpy（OCT）.The mean follow-up period was 15 months.Results At the last follow-up,the visual acuity was improved in 10 eyes（25.64%）,stabilized in 23 eyes（58.97%）,and decreased in 6 eyes（15.38%）.FFA and OCT showed complete closure of CNV in 17 eyes（43.59%）,partial closure in 9 eyes（23.07%）,incomplete closure in 8 eyes（20.51%） and recurrence in 5 eyes（12.82%）.Conclusion PDT is safe and effective in treatment of subfoveal CNV.

关 键 词：脉络膜新生血管化 光化学疗法 黄斑病变 

分 类 号：R774.5[医药卫生—眼科]